龋病、牙髓病，口腔生物学的研究

1.开创了利用DNA疫苗等免疫技术预防龋病的新领域;2.促进我国牙髓病的临床研究:如改进和完善牙髓病治疗技术;对”C”型根管进行了深入研究,促进了牙髓病学的发展;3.是我国开创和推动”口腔生物学”学科发展的早期倡导者之一。省部级科技奖6项。培养博士31名、60名。

自1991年起享受国务院政府特殊津贴；1994年被评为国家级有突出贡献的中青年专家。

代表性论文 :

1.Jia Rong , Guo Jihua , Fan Mingwen* , Bian Zhuan , Chen Zhi , Fan Bing , Yu Fei, Xu Qingan . Immunogenicity of CTLA4 fusion anti-caries DNA vaccine in rabbits and monkeys. Vaccine , 2006 ;24:5192-5200

2.Shen Jing, Fan Mingwen*, Chen Xinming, Wang Shuozhi,Wang Li, Li Yuan. Glandular Odontogenic Cyst in China:Report of 12 Cases and Immunohistochemical Study. J Oral Pathology & Medicine 2006, 35:175-82

3.Xu Qiong, Fan Mingwen*, Bing Fan , GSP Cheung , Hanlin Hu. A new quantitative method using glucose for analysis of endodontic leakage. Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodonitics 2005; 99:107-111

4.Xu Qing’an , Yu Fei , Fan Mingwen* , Bian Zhuan , Guo Jihua , Jia Rong ,. Chen Zhi , Peng Bin , Fan Bing . 2005 . Immunogenicity and protective efficacy of a targeted fusion DNA construct against dental caries . Caries Research 2005;39:422-431

5.Xue Jingling, Fan Mingwen*, Wang Shuozhi, Chen Xinming, Li Yuan, Wang Li. A clinical study of 674 patients with oral lichen planus in China. Journal of Oral Pathology & Medicine 2005;34 (8): 467-472

6.Li Yuhong, Fan Mingwen*, Bian Zhuan, Chen Zhi, Peng Bing, Guo Jihua .Chitosan microparticles intended for anti-caries DNA vaccine mucosal delivery: synthesis, characterization and transfection. J Wuhan University of Technology, Materials Science Edition.2005;20(2):35-38

7.Li Yuhong, Fan Mingwen*, Bian Zhuan, Chen Zhi, Zhang Qi, Yang HR.Chitosan-DNA microparticles as mucosal delivery system: synthesis, release and distribution. Chinese Medical Journal .2005; 118 (11):936-941

8.Bing Fan, Gary S. P. Cheung, Mingwen Fan*, James L. Gutmann, Zhuan Bian. C-shaped Canal System in Mandibular Second Molars: Part-I—Anatomical Features. Jounal of Endodontics 2004;30:899-903

9.Bing Fan, Gary S. P. Cheung, Mingwen Fan*, James L. Gutmann and Wei Fan. C-shaped Canal System in Mandibular Second Molars: Part-II—Radiographic Feature. Jounal of Endodontics 2004;30:904-908

10.Rong Jia, Jihua Guo, Mingwen Fan*, Zhuan Bian, Zhi Chen, Bin Peng, Bing Fan. Mucosal immunization against dental caries with plasmid DNA encoding pac gene of Streptococcus mutans in rats. Vaccine 2004;22 2511–2516

11.Guo JH, Jia R, Fan MW*, Bian Z, Chen Z, Peng B..Construction and immunogenic characterization of a fusion anti-caries DNA vaccine against PAc and 2glucosyltransferase I of Streptococcus mutans . Journal of Dental Research 2004 ;83 (3): 266-270

12.Hongkun Wu, Mingwen Fan*, Xuedong Zhou, Anchun Mo, Zhuan Bian, Qi Zhang, Zhi Chen. Detection of Streptococcus mutans and Streptococcus sobrinus on the Permanent First Molars of the Mosuo People in China. Caries Research 2003;37:374-380

13.Mingwen. Fan*, Zhuan. Bian, Zhixiang. Peng, Yan. Zhong, Zhi. Chen, Bin. Peng, and Rong. Jia. A DNA Vaccine Encoding a Cell-surface Protein Antigen of Streptococcus mutans Protects Gnotobiotic Rats from Caries. J Dent Res 2002;81(11):784-787

14.Min Nie, Mingwen Fan*, Zhuan Bian. Transmission of mutans streptococci in adults within Chinese population. Caries Research. 2002;36(3):161-166

中华口腔医学会副会长

湖北省医学会副会长

国务院学位委员会口腔学科评议组召集人

人民卫生出版社口腔医学教材编审委员会主任委员

国际牙科研究协会中国分会执行主席

国际牙科研究协会地区发展委员会委员

成人牙髓干细胞的鉴定、分化特征及诱导牙髓再生的研究教育部博士点基金2002~2005

龋病预防和治疗的分子机制研究武汉大学科创基金2002~2005

DNA防龋疫苗及免疫防龋制剂研制及开发省科技攻关计划2002~2005

靶向融合防龋DNA疫苗的研制和粘膜免疫防龋的作用机制国家自然科学基金面上项目2002~2005

被动免疫防龋生物制品——特异性鸡蛋黄抗体喷雾省科技攻关计划2003~2005

靶向DNA疫苗激发粘膜免疫反应机制的研究国家自然科学基金重点项目2003~2006

中草药活性成份预防口腔疾病省教委基金2002~2005

靶向融合防龋DNA疫苗的临床前研究和开发武汉市科技攻关计划2006-2008