肖英莲

医疗特长：对消化系统常见疾病（包括慢性胃炎、消化性溃疡、炎症性肠病、慢性肝胆疾病、功能性胃肠病等）的诊断与治疗有丰富的临床经验；熟练掌握消化内镜技术。擅长各种功能性胃肠病及胃肠动力障碍性疾病尤其是胃食管反流病及食管动力障碍性疾病的诊治。研究方向：功能性胃肠病，胃食管反流病及食管动力障碍性疾病临床与转化医学研究。主要教育和工作经历：2003年毕业于中山大学中山医学院，之后相继获硕士、博士学位，自毕业后即于中山大学附属第一医院消化内科工作至今。2011年获得卫生部重点学科基金资助，在美国芝加哥西北大学西北纪念医院食管疾病中心从事访问学者工作1年。社会兼职：目前为亚洲神经胃肠动力协会青年委员，中华医学会消化分会第十一届委员会青年委员会副主任委员及动力学组副组长，中华医学会消化分会食管协作组委员，广东省医学会消化分会动力学组副组长，同时为国外多个杂志包括Disease of esophagus, journal of gastroenterology and hepatology, neurogastoenterology & motility等的特邀审稿人。第一作者/通讯作者论著1. Xiao Y, Li Y, Shu J, Li Y, Xu J, Ren J, Liu D, Wang J, Zhou L, Li Y, Tang G, Tian D, Zhang S, Hou X, Wang H, Li Z, Lv N, Chen M.The efficacy of oral Zhizhu Kuanzhong, a Traditional Chinese Medicine, in patients with postprandial distress syndrome.J Gastroenterol Hepatol. 2018 Sep 11. doi: 10.1111/jgh.14467. [Epub ahead of print]2. Xiao Y, Lin Z, Li Y, Pandolfino JE, Chen M, Kahrilas PJ. Correlation between novel 3D high-resolution manometry esophagogastric junction metrics and pH-metry in reflux disease patients.Neurogastroenterol Motil. 2018 Sep;30(9):e13344.3. Mengyu Zhang, Minhu Chen, Sui Peng, Yinglian Xiao*. The Rome IV versus Rome III criteria for heartburn diagnosis: A comparative study. United European Gastroenterology Journal 2018, 6(3): 358–3664. Xie C, Sifrim D, Li Y, Chen M, Xiao Y*. Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment. J Neurogastroenterol Motil. 2018 Jan 30;24(1):43-50.5. Xiao Y*, Carlson DA, Lin Z, Alhalel N, Pandolfino JE. Jackhammer esophagus: Assessing the balance between prepeak and postpeak contractile integral. Neurogastroenterol Motil. 2017 Nov 29. doi: 10.1111/nmo.13262. [Epub ahead of print]. 6. Li YW, Sifrim D, Xie C, Chen M, Xiao YL*. Relationship Between Salivary Pepsin Concentration and Esophageal Mucosal Integrity in Patients With Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2017 Oct 30;23(4):517-525. 7. Xiao Y*, Carlson DA, Lin Z, Rinella N, Sifrim D, Pandolfino JE. Assessing the pre- and postpeak phases in a swallow using esophageal pressure topography.Neurogastroenterol Motil. 2017 Sep;29(9).8. Xie, C.; Li, Yuwen; Zhang, Ning.; Xiong, Lishou; Chen, Minhu.; Xiao, Yinglian*. Gastroesophageal flap valve reflected EGJ morphology and correlated to acid reflux.BMC Gastroenterology. 2017 Nov 22;17(1):118. 9. Zhiyue Lin#, Yinglian Xiao#, Yuwen Li, John E. Pandolfino, Minhu Chen*, Peter J. Kahrilas*.Novel 3D high-resolution manometry metrics for quantifying esophagogastric junction contractility. Neurogastroenterol Motil.2017 Aug;29(8).10. Xie, C.; Wang, J.; Li, Y.; Tan, N.; Cui, Y.; Chen, M.; Xiao, Y*.Esophagogastric Junction Contractility Integral Reflect the Anti-reflux Barrier Dysfunction in Patients with Gastroesophageal Reflux Disease.J Neurogastroenterol Motil. 2017 Jan 30;23(1):27-33. 11. Li, Y. W.; Xie, C. X.; Wu, K. M.; Chen, M. H.; Xiao, Y. L*.Motility characteristics in the transition zone in Gastroesophageal Reflux Disease (GORD) patients.BMC Gastroenterol 2016, 16, 106. 12. Xiao Y, Liang M, Peng S, Zhang N, Chen M*. Tailored therapy for the refractory GERD patients by combined multichannel intraluminal impedance-pH monitoring.J Gastroenterol Hepatol.2016 Feb;31(2):350-4. 13. Shi Y#, Tan N#, Zhang N, Xiong L, Peng S, Lin J, Chen M, Xiao Y*.Predictors of proton pump inhibitor failure in non-erosive reflux disease: A study with impedance-pH monitoring and high-resolution manometry.Neurogastroenterol Motil. 2016 Jan 1414. Xiao Y,Kahrilas PJ,Nicodème F,Lin Z,Roman S,Pandolfino JE.Lack of Correlation Between HRM Metrics and Symptoms During the Manometric Protocol. Am J Gastroenterol. 2014; 109(4):521-6 15. Xiao Y, Kahrilas PJ, Kwasny MJ, Roman S, Lin Z, Nicodème F, Lu C, Pandolfino JE. High-Resolution Manometry Correlates of Ineffective Esophageal Motility. Am J Gastroenterol. 2012; 107(11):1647-54 16. Xiao Y, Nicodème F, Kahrilas PJ, Roman S, Lin Z, Pandolfino JE. Optimizing the swallow protocol of clinical high-resolution esophageal manometry studies. Neurogastroenterol Motil. 2012 Oct;24(10):e489-96.17. Xiao Y, Read A, Nicodème F, Roman S, Kahrilas PJ, Pandolfino JE.The effect of a sitting vs supine posture on normative esophageal pressure topography metrics and Chicago Classification diagnosis of esophageal motility disorders. Neurogastroenterol Motil. 2012 Oct;24(10):e509-16.18. Xiao YL, Peng S, Tao J, Wang AJ, Lin JK, Hu PJ, Chen MH.Prevalence and symptom pattern of pathologic esophageal acid reflux in patients with functional dyspepsia based on the Rome III criteria. Am J Gastroenterol. 2010 Dec;105(12):2626-31. 19. Xiao YL, Lin JK, Cheung TK, Wong NY, Hung IF, Wong BC, Peng S, Wang AJ, Chen MH. Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring. J Gastroenterol Hepatol. 2009;24(6):1113-1118. 20. Xiao YL, Lin JK, Cheung TK, Wong NY, Yang L, Hung IF, Wong BC, Chen MH. Normal values of 24-hour combined esophageal multichannel intraluminal impedance and pH monitoring in the Chinese population. Digestion. 2009;79(2):109-114. 21. Xiao YL, Liu FQ, Li J, Lv JT, Lin JK, Wen WP, Chen MH.Gastroesophageal and laryngopharyngeal reflux profiles in patients with obstructive sleep apnea/hypopnea syndrome as determined by combined multichannel intraluminal impedance-pH monitoring. Neurogastroenterol Motil. 2012 Jun;24(6):e258-65.22. Xiao YL, Carson D,Boris L, et al. Theacousticcoughmonitoringandmanometricprofileofcoughandthroatclearing. Dis Esophagus.2014; 27(1):5-12 23. Xiao YL, Nie YQ, Hou XH, Xie PY, Fang JY,Yuan YZ, Zhou LY, Zhao NQ, Chen MH. The efficacy, safety and cost-effectiveness of hydrotalcite versus esomeprazole in on-demand therapy of NERD: A multicenter, randomized, open-label study in China. J Dig Dis. 2013 Sep;14(9):463-8. doi: 10.1111/1751-2980.12069. 其他主要工作成绩：主持及参与国家级、省部级基金近10项，其中作为第一主持人获得了国家自然科学基金面上基金及青年基金各一项，广东省科技厅博士启动基金项目一项，教育部博士点新教师基金一项。2010年入选中山大学附属第一医院优秀青年人才培养计划。在多个大型国际学术会议上获得交流机会；参编专著3部。目前在这一研究领域发表SCI论文近50篇，其中署名第一/通讯作者论著23篇，影响因子超过10分的文章3篇。研究结果为2013年国际及2014年国内胃食管反流病共识意见所引用，并作为亚洲地区的唯一专家参与了2014年胃食管反流病检测技术的共识意见及2016年更新的胃食管反流病国际共识制定，同时为2014年中国胃食管反流病共识意见的主要作者。该系列研究成果荣获2013年广州市科技奖励一等奖。2013年及2014年受邀在国际会议上做专题汇报。2016年在消化领域最高级的会议“美国消化疾病周”做口头发言，获得“杰出青年研究者”称号。2017年在亚洲胃肠动力年会获得“青年医师研究奖”。

胃肠动力障碍性疾病的诊治，尤其是胃食管反流病、贲门失迟缓，食管痉挛等疾病，包括吞咽困难，吞咽梗阻感，胸痛，烧心和反流等症状。