Research Focus:Research in the Uterine Vascular Biology Laboratory focuses on 4 main themes。1、 Regulators of trophoblast invasionInvasion of the maternal decidua and inner third of myometrium by extravillous trophoblast cells and the subsequent remodeling of the uterine spiral arteries is one of the key events in early pregnancy; failures in these processes being associated with major complications of pregnancy。 Our research aims to identify some of the key regulatory mechanisms in these processes with the ultimate aim to develop early interventions for prevention of these pregnancy complications。2、 Regulators of VSMC (de)differentiationVascular smooth muscle cells can switch from a synthetic to contractile phenotype and vice versa depending on the microenvironment。 The switch from contractive to synthetic is a key feature of spiral artery remodeling and we have identified Ang2 and vitamin D as one of the key mediators of this process。 Our research aims to understand the molecular basis of this phenotypic switching and how it can be utilized therapeutically。3、Regulators of endometrium maturation in health and disease (recurrent miscarriage, heavy menstrual bleeding, endometriosis)Aberrant endometrial maturation is a feature of recurrent miscarriage (advanced) and heavy menstrual bleeding (halted) associated with TGF-β1 signalling。 Current research is focused on understanding the complete molecular basis of this to develop therapeutics for these important gynecology conditions。4、 Regulators of tumor angiogenesis, metastasis and progression (breast, endometrial and ovarian)Poor prognosis for many types of tumors is associated with tumor angiogenesis and cancer cell metastasis。 Many of the same pathways being investigated in the tightly regulated process of trophoblast invasion/spiral artery remodeling are also relevant to tumor angiogenesis and metastasis where they occur in an uncontrolled manner。 Therefore we can learn about both systems by drawing parallels between them。Research Personnel:? Senior scientisto Dr Qi Yifeio Dr Zhao Mingguango Dr Ning Feno Dr Chen Miaojuan? Post-doctoral fellowso Dr Lu Qinshengo Dr Wang Qiong (secondary tutor with Dr Shi Kun)o Dr Duan Yaoyuan? Technicianso Miss Wu Peihuango Miss Dan Weio Mr Sun Dingqian? Masters studentso Miss Hou Huomeio Miss Zhang Mino Miss Pan Yue? Past post-doctoral traineeso Dr Zhang Joy YueInternational collaborations:Professors Mark Kilby and Martin Hewison (University of Birmingham, UK) – Vitamin D and early pregnancyDr Annette Meeson (Newcastle University, UK) – Cancer stem cells and angiogenesisProfessor Jan Ernerudh (University of Linkoping, Sweden) – Regulation of immune cells in early pregnancyResearch Grants Awarded:2018-2022 Angiopoietin-2 induces vascular smooth muscle cell dedifferentiation after binding to integrin subunits。 NSFC Project Grant 580,000RMB。 Lash GE (PI)2017-2020 Is endometrial growth and maturation dependent on TGF-β1? NSFC Project Grant 570,000RMB。 Lash GE (PI)2017-2020 The role of vitamin D deficiency in the aetiology of low birth weight pregnancies。 Guangzhou Municipal Grant (collaboration with University of Birmingham) 2,000,000RMB。 Lash GE (PI), Qiu X, Kilby MD, Hewison M国家自然科学基金青年年项目,C080904,Noda1疫茴刈恶性黑色素瘤的防治作用及机制研究,2017/1-2019/12, 20万元,在研,参加国家自然科学基金青年科学基金项目,项目编号:81702567,HE4通过Smad信号通路对子宫内膜癌细胞周期的调控机制研究,2018/01-2020/12,20万,在研,参加Research Awards and Fellowships:2016 Guangzhou Medical Key Talent2016 Visiting Scholar, College of Veterinary Medicine, Michigan State University, Michigan, USASelected recent publications:Bulmer JN, Lash GE (2019) Uterine natural killer cells: Time for a re-appraisal? F1000Res8。 Pii: F1000 Faculty Rev-999。Ning F, Hou H, Morse AN, Lash GE。 (2019) Understanding and management of gestational trophoblastic disease。 F1000Res。 8。 pii: F1000 Faculty Rev-428。Wang J, Zhang JY, Wei R, Hu S, Lin T, Lash GE, Tan M (2019) Serum 25 hydroxyvitamin D status, vitamin D supplementation and feeding patterns in 6-month-old infants in Guangzhou, China: a paired longitudinal follow up study。 Maternal and Child Nutrition Accepted (IF: 3.233)Otun HA, Innes BA, Lash GE, Schiessl B, Ball E, Searle RF, Robson SC, Bulmer JN (2019) Quantification of spiral artery remodelling in human placental bed using an Adobe Photoshop based image analysis technique。 Reproduction In press (IF: 3.450)Lu Q, Huang Y, Wu J, Guan Y, Du M, Wang F, Liu Z, Zhu Y, Gong G, Hou H, Zhang M, Zhang JY, Ning F, Zhou Q, Chen L, Wang L, Lash GE (2019) T-cadherin inhibited invasion and migration of endometrial stromal cells in endometriosis。 Human Reproduction In press (IF: 5.505)Manning R, James CP, Smith MC, Innes BA, Stamp E, Peebles D, Baja-Elliott M, Klein N, Bulmer JN, Robson SC, Lash GE (2019) Predictive value of cervical cytokine, antimicrobial and microflora levels for pre-term birth in high-risk women。 Scientific Reports 9:11246。 (IF: 4.122)Li L, Qiu X, Lash GE, Yuan L, Liang Z, Liu L。 (2019) Effect of hormone replacement therapy on bone mineral density and body composition in Chinese adolescent and young adult Turner syndrome patients。 Frontiers in Endocrinology 10:377 (IF: 3.519)Robson A, Lash GE, Innes BA, Robson SC, Bulmer JN (2019) Uterine natural killer cells mediate dedifferentiation of spiral artery vascular smooth muscle cells in early human pregnancy。 Human Reproduction 34:1428-1438 (IF: 5.505)Zhang JY, Wang J, Hu S, Chen D, Lu Q, Wei R, Tan M, Lash GE (2019) Cord serum vitamin D levels in a South China birth cohort。 Asian Pacific Journal of Clinical Nutrition 28:544-549。 (IF: 1.335)Oldershaw R, Owens A, Sutherland R, Linney M, Liddle R, Magana L, Lash GE, Gill JH, Richardson G, Meeson A (2019) Human cardiac mesenchymal stem cell like cells, a novel cell population with therapeutic potential。 Stem Cells and Development 28:593-607。 (IF: 3.315)Li L, Li Q, Wang Q, Liu L, Li R, Liu H, He Y, Lash GE (2019) Rare copy number variants in the genome of Chinese female children and adolescents with Turner syndrome。 Bioscience Reports 39: pii: BSR20181305。 (IF: 2.899)Jiang M, Lash GE, Zhao X, Long Y, Guo C, Yang H (2018) CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential novel biomarkers for the prediction of preeclampsia。 Cellular Physiology and Biochemistry 46:2576-2586。 (IF: 5.5)Shi K, Wang Q, Su Y, Xuan X, Liu Y, Chen W, Qian Y, Lash GE (2018) Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma。 Cancer Science 109:1032-1043。 (IF: 4.372)Biswas Shivhare S, Bulmer JN, Innes BA, Hapangama DK, Lash GE (2018) Endometrial vascular development in menorrhagia: altered spatio-temporal pattern of expression of endothelial cell markers and extracellular matrix components。 Human Reproduction 33:399-410。 (IF: 5.505)Lindau R, Mehta RB, Lash GE, Papapavlou G, Boij R, Berg G, Jenmalm MC, Ernerudh J, Svensson-Arvelund J (2018) Interleukin-34 is present at thefetal–maternal interface and induces immunoregulatory macrophages of a decidual phenotype in vitro。 Human Reproduction 33:588-599。 (IF: 5.505)Wang Q, Lash GE (2017) Angiopoietin 2 in placentation and tumor biology: the yin and yang of vascular biology。 Placenta。 56:73-78。 (IF: 2.434)Liu ZC, Ning F, Wang HF, Chen DY, Cai YN, Sheng HY, Lash GE, Liu L, Du J。 (2017) Epidermal growth factor and tumor necrosis factor α cooperatively promote the motility of hepatocellular carcinoma cell lines via synergistic induction of fibronectin by NF-κB/p65。 Biochim Biophys Acta。 1861:2568-2582。 (IF: 3.679)Ning F, Liu H, Lash GE (2016) The role of decidual macrophages during normal and pathological pregnancy。 Am J Reprod Immunol。 75:298-309。 (IF: 2.745)Laird SM, Lash GE, Li TC, Bulmer JN (2016) The role of natural killer cells in human fertility。 Scientific Impact Paper No。 53。 Royal College of Obstetrics and Gynecology。 https://www.rcog.org.uk/en/guidelines-research-services/guidelines/the-role-of-natural-killer-cells-in-human-fertility-scientific-impact-paper-no。-53/Shi K, Liu L, He YJ, Y LX, Lash GE, Li L (2016) Body composition and bone mineral status in patients with Turner syndrome。 Scientific Reports 6:38026。 (IF: 4.122)Lash GE, Bulmer JN, Li TC, Innes BA, Mariee N, Patel G, Sanderson J, Quenby S, Laird SM (2016) Standardisation of uterine natural killer (uNK) cell measurements in the endometrium of women with recurrent reproductive failure。 J Reprod Immunol 116:50-59。 (IF: 2.232)Lash GE, Pitman H, Morgan HL, Innes BA, Agwu CN, Bulmer JN (2016) Macrophages: key regulators of vascular remodelling in human pregnancy。 J Leukoc Biol 100:315-325。 (IF: 4.224)Biswas Shivhare S, Bulmer JN, Innes BA, Hapangama DK, Lash GE (2015) Menstrual cycle distribution of uterine natural killer cells is altered in menorrhagia。 J Reprod Immunol 112:88-94。 (IF: 2.232)Lantang AM, Innes BA, Gan EH, Pearce SH, Lash GE (2015) Expression of melanocortin receptors in human endometrium。 Hum Reprod 30:2404-10。 (IF: 5.505)Svensson-Arvelund J, Mehta RB, Lindau R, Mirrasekhian E, Rodriguez-Martinez H, Berg G, Lash GE, Jenmalm MC, Ernerudh J (2015) The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages。 J Immunol 194:1534-44。 (IF: 4.539)
时段 | 05-22周三 | 05-23周四 | 05-24周五 | 05-25周六 | 05-26周日 | 05-27周一 | 05-28周二 |
---|---|---|---|---|---|---|---|
上午 | |||||||
下午 | |||||||
晚上 |
- 耳鼻咽喉科(听力学)
- 免疫科
- 心内科
- 呼吸科
- 神经康复科
- 内科
- 泌尿外科
- 小儿普通外科
- 骨科
- 消化科
- 肾内科
- 新生儿内科(含NICU)
- 儿童保健科
- 皮肤科
- 胸外科
- 感染科
- 血液肿瘤科
- 内分泌代谢科
- 颅脑外科
- 急诊科
- 眼科
- 口腔科
- 介入血管瘤科
- 中医儿科
- 肿瘤外科
- 临床营养科
- PICU
- 心理科
- 病毒研究室
- 理疗科
- 麻醉科
- 新生儿外科
- 肝胆外科
- 心脏中心
- 耳鼻咽喉科(睡眠学)
- CT室
- 外科门诊
- 新生儿ICU
- 外科
- 内分泌专科
- 儿内科
- 皮肤科
- 眼科
- 呼吸专科
- 隔离
- 耳鼻喉科
- 口腔科
- 中医
- 康复
- 消化专科
- 介入
- 特诊
- 儿童康复理疗科
- 血液专科
- 新生儿科
- 耳鼻咽喉科
- 影像中心
- 生殖医学中心
- 小儿肾内科
- 中心实验室
- 儿科
- 肿瘤专科
- 血液科
- 中医科
- 过敏免疫风湿病科
- 儿童早期发展中心
- 儿科急诊
- 儿科重症监护室(PICU)
- 遗传内分泌科
- 新生儿科(含NICU)
- 儿童保健门诊
- 门诊普儿科
- 免疫及风湿病科
- 神经内科
- 感染性疾病科
- 神经外科
- 胃肠专科
- 乳腺外科
- 麻醉与围术期科
- 成人男科
- 盆底康复中心
- 产科
- 产房
- 肿瘤妇科
- 产科特需病房
- 产控中心
- 生殖内分泌科
- 盆底与泌尿妇科
- 妇科门诊手术室
- 药学部
- 病理科
- 检验科
- 输血科
- 放射科
- 超声科
- 新生儿筛查中心
- 产前诊断中心
- 脐血库
- 临床数据中心
- 免疫学
- 干细胞与心血管修复研究
- 2023-11-21做胃镜需要空腹多久
- 2023-11-21玩含手工胶水的水晶泥史莱姆会得白血病吗
- 2023-11-17多发性肝囊肿2厘米
- 2023-11-17打呼噜憋气跟抽烟有关吗
- 2023-11-16简述戴近视眼镜矫正的原理
- 2023-11-15耳聋隐性基因遗传概率
- 2023-11-15二胎孕妇耳聋基因阳性是啥意思
- 2023-11-15关于新生儿耳聋基因筛查
- 2023-11-15多发肝囊肿是脂肪肝引起吗
- 2023-11-15牙周炎吃钙维生素D可以吗