各种病毒性肝炎及肝病的诊治研究

游晶，女，泰国宋卡王子大学医学博士，教授，主任医师，硕士生导师，云南省中青年学术和技术带头人，昆明医学院骨干教师，师从于国际著名医学家VirasakdiC.教授、HutchaS.教授及AlanG.教授。自1984年工作后一直从事内科学、感染病学的临床、科研和教学工作。多次被评为职业道德先进个人、先进工作者、优秀医师、优秀教师等。主持/参加完成国际科研基金项目、省级科研基金项目、卫生部国际合作项目等10多项。在国内外核心期刊发表学术论文60余篇，被美国科学引文索引（SCI）收录12篇。获科技成果奖多项。参加国际学术会议进行学术交流20多次。国内外多家杂志（HepatologyInternational,EuropeanJournalofGastroenterologyandHepatology,WorldJournalofGastroenterology,JournalofMedicalVirology,ClinicalEpidemiology,ClinicalHepatology,PhilippineJournalScience,CurrentTopicinVirology,JournalofClinicalHepatology,WorldJournalofInfection,etal）编委及审稿专家。擅长各种病毒性肝炎及肝病的临床诊断治疗和科学研究。近五年来在国内外核心期刊发表的主要论著：[1]JingYou,LinZhuang,Yi-FengZhang,Hong-YingChen,HutchaSriplung,AlanGeater,VirasakdiChongsuvivatwong,TeerhaPiratvisuth,EdwardMcNeil,LanYu,Bao-ZhangTang,Jun-HuaHuang.PeripheralT-lymphocytesubpopulationsindifferentclinicalstagesofchronicHBVinfectioncorrelatewithHBVload.WorldJGastroenterol2009;15(27):3382-3393（SCI收录）[2]JingYou,HutchaSriplung,AlanGeater,VirasakdiChongsuvivatwong,LinZhuang,Yun-LiLi,HuaLei,JunLiu,Hong-YingChen,Bao-ZhangTang,Jun-HuaHuang.ImpactofviralreplicationinhibitionbyentecavironperipheralTlymphocytesubpopulationsinchronichepatitisBpatients.BMCIntectiousDiseases,2008,8:123（SCI收录）[3]JingYou,HutchaSriplung,VirasakdiChongsuvivatwong,AlanGeater,LinZhuang,Jun-HuaHuang,Hong-YingChen,LanYu,Bao-ZhangTang.Profile,spectrumandsignificanceofhepatitisBvirusgenotypesinchronicHBV-infectedpatientsinYunnan,China.HepatobiliaryPancreatDisInt2008;7(3):271-279（SCI收录）[4]JingYou,HutchaSriplung,AlanGeater,VirasakdiChongsuvivatwong,LinZhuang,Hong-YingChen,LangYu,Bao-ZhangTang,Jun-HuaHuang.EffectofviralloadonT-lymphocytefailureinpatientswithchronichepatitisB.WorldJGastroenterol,2008,14(7):1112-1119（SCI收录）[5]JingYou,HutchaSriplung,AlanGeater,VirasakdiChongsuvivatwong,LinZhuang,Hong-YingChen,Jun-HuaHuang,Bao-ZhangTang.HBVDNAismorepowerfulthanHBeAginpredictingperipheralT-lymphocytesubpopulationinchronicHBV-infectedindividualswithnormalliverfunctiontests.WorldJGastroenterol,2008,14(23):3710-3718（SCI收录）[6]JingYou,LinZhuang,Hong-YingCheng,Shou-MingYan,LanYu,Jun-HuaHuang,Bao-ZhangTang,Meng-LingHuang,Yong-LiangMa,VirasakdiChongsuvivatwong,HutchaSriplung,AlanGeater,Yan-WeiQiao,Rong-XueWu.EfficacyofThymosinalpha-1andInterferonalphaintheTreatmentofChronicViralHepatitisB:ARandomizedControlledStudy.WorldJGastroenterol2006,12(41):6715-6721（SCI收录）[7]YanhuaChe,SawitriAssanangkornchai,EdwardMcNeil,VirasakdiChongsuvivatwong,JianhuaLi,AlanGeater,JingYou.PredictorsofearlydropoutinmethadonemaintenancetreatmentprograminYunnanprovince,China.DrugAlcoholRew2010;29(3):263-7（SCI收录）[8]YanhuaChe,SawitriAssanangkornchai,EdwardMcNeil,JianhuaLi,JingYou,VirasakdiChongsuvivatwong.PatternsofattendanceinmethadonemaintenancetreatmentprograminYunnanProvince,China.AmJDrugAlcoholAbuse2011;37(3):148-54（SCI收录）[9]BaoZhangTang,JingYou,HongYingChen,LuZhang,GaoChen.TherapeuticeffectofLamivudineonsubacutehepaticfailurewithhepatitisBvirusinfection.CurrentTopicsinVirology,2007;6:41-45[10]JingYou,Li-FanYuan,Yi-FengZhang,Hai-QiuYang,LinZhuang,Hong-YingChen,Jun-HuaHuang,Bao-ZhangTang,HuiWang.TherelationshipofperipheralTcellsubsetsandserumtransforminggrowthfactorβ1levelinpatientswithchronichepatitisBvirusinfection.HepatolInt,2009,3:35[11]JingYou,LinZhuang,HutchaSriplung,AlanGeater,VirasakdiChongsuvivatwong,Yun-LiLi,HuaLei,JunLiu,Hong-YingChen,Bao-ZhangTang,Jun-HuaHuang.Entecavirtherapyforupto48weeksinChinesepatientswithHBeAg-positivechronichepatitisB.HepatolInt,2009,3:119[12]LinZhuang,JingYou,Yi-FengZhang,Yun-LiLi,HuaLei,Rui-DongYang,Hong-YingChen,Jun-HuaHuang,Bao-ZhangTang.Adefovirdipivoxilfortreatmentoflamivudine-resistanthepatitisBeantigen-positivechronichepatitisB.HepatolInt,2009,3:133[13]JingYou,XuZhang,LinZhuang,Hong-YingChen,Bao-ZhangTang,Qing-QingWang,LiChen.TherelationshipbetweenHBVprecoreregionmutationandthevariationofT-lymphocytesubpopulationsinpatientswithchronichepatitisB.IntJInfectDis,2009,13(Suppl1):S72[14]LinZhuang,JingYou,Hong-YingChen,Bao-ZhangTang,Meng-LingHuang,Yong-LiangMa,Jun-HuaHuang,Rong-XueWu.Thymosinalpha-1therapyinChinesepatientswithchronichepatitisB:resultsfromarandomizedcontrolledclinicaltrial.IntJInfectDis,2009,13(Suppl1):S80[15]JingYou,Fang-RongZhang,XuZhang,HuiWang,Li-FangYuan,Hong-YingChen,Qion-FenLi,Guo-YanBai,LinZhuang,Bao-ZhangTang,Jun-HuaHuang.Thevariationofserumlevelofinterleukin-15andit’ssignificancesinpatientswithchronichepatitisBvirusinfection.HepatolInt,2010,4:103[16]JingYou,HuiWang,Hong-YingChen,Yi-HuiChen,Zhi-WenDuan,Xing-XingShi,Li-WenYang,Yan-PingLiang,LinZhuang,Bao-ZhangTang,Jun-HuaHuang.ThevariationofperipheralT-lymphocytesubpopulationsandserumInterferon-γandInterleukin-4levelinpatientswithchronichepatitisBvirusinfection.HepatolInt,2010,4:112[17]JingYou,LinZhuang,Hong-YingChen,Jun-HuaHuang,Bao-ZhangTang,Meng-LinHuang.VariationinliverhistopathologyinchronicHBV-infectedindividualswithnormalliverfunctiontestscorrelateswithHBVreplication.HepatolInt,2010,4:16[18]LinZhuang,JingYou,LeiKong,HuaLei,Rui-DongYang,XuZhang,Qing-QingWang.Efficacyof96weeksadefovirdipivoxiltreatmentinHBeAgpositivechronichepatitisBpatientswithvariousbaselinebiochemicallevels.HepatolInt,2010,4:19[19]JingYou,Qing-QingWang,LinZhuang,XiaFeng,Rui-DongYang,RongLiu,Hong-YingChen,Hui-JuanYang,Qiang-MingSun,Yong-ShengZhang,Qiong-FengLi,LiChen,Hai-QiuYang,Yi-FengZhang,HongDai,Zhi-WenDuan.TheroleofInterleukin-12p70indenguevirusinfection.IntJInfectDis,2010,14S2:S14[20]LinZhuang,JingYou,LeiKong,HuaLei,Hong-YingChen,Qing-QingWang.PrevalenceofTransfusiontransmittedvirusinpatientswithviralliverdisease.IntJInfectDis,2010,14S2:S57[21]JingYou,XiaFeng,Rui-DongYang,RongLiu,Qing-QingWang,Hong-YingChen,Hui-JuanYang,Qiang-MingSun,Yong-ShengZhang,Qiong-FengLi,LiChen,Hai-QiuYang,Yi-FengZhang,HongDai,Zhi-WenDuan.AshiftfromaTh1toaTh2immuneresponseinpatientswithdenguevirusinfection.IntJInfectDis,2010,14S2:S94[22]JingYou,LinZhuang,Hong-YingChen,XiaFeng,Yan-HuaChe,Ying-LiCun,Yi-FengZhang,Yon-ShengZhang,Bao-ZhangTang,Meng-LingHuang,Yong-LiangMa,Jun-HuaHuang,Shao-MingYan,Qing-QingWang,LiChen,ChaoChen,Jun-MinLi.InterferontherapydecreasedtheincidenceofhepatocellularcarcinomainpatientswithchronichepatitisB:aprospectivecohortstudy.HepatolInt,2011,5:102[23]LinZhuang,JingYou,Shao-MingYan,Jun-HuaHuang,LeiKong,HuaLei,Yan-LiMa,Yun-LiLi,Hong-YingChen,Bao-ZhangTang,Qing-QingWang,XuZhang,LiChen,Jun-MingLi,ChaoChen.Long-termtherapywithadefovirdipivoxilforlamivudine-resistantHBeAgpositivechronichepatitisB:resultsfrom104weeksantiviraltreatment.HepatolInt,2011,5:109[24]JingYou,LinZhuang,Hong-YingChen,XiaFeng,LeiKong,HuaLei,Yan-LiMa,Yun-LiLi,Wei-BoYang,Jun-HuaHuang,Shao-MingYan,Yan-HuaChe,Qing-QingWang,LiChen.Long-termtherapywithadefovirdipivoxilforHBeAgpositivechronichepatitisB:resultsfrom144weeksadefovirdipivoxiltreatment.IntJInfectDis,2011,15S2:S30[25]JingYou,LinZhuang,Jun-HuaHuang,Yan-HuaChe,Shao-MingYan,HuaLei,LeiKong,Yun-LiLi,Hong-YingChen,Bao-ZhangTang,Qing-QingWang,Yan-LiMa,LiChen,Hai-BingWang.SeverityofhepaticinflammationandfibrosisinpatientswithchronicHBVinfectionwithnormalliverfunctiontestcorrelatedwithviralloadandHBeAgstatus.IntJInfectDis,2011,15S2:S69[26]LinZhuan,JingYou,Shao-MingYan,Jun-HuaHuang,LeiKong,HuaLei,Yan-LiMa,Yun-LiLi,Hong-YingChen,Bao-ZhangTang,Qing-QingWang,XuZhang,LiChen,Hai-BingWang,Jun-MingLi,ChaoChen.HBVandHCVinfectionplayanimportantroleintheprogressiontolivercirrhosisandhepatocellularcarcinomainalcoholics.IntJInfectDis,2011,15S2:S69[27]游晶,庄林,马永良,唐宝璋.慢性乙型肝炎的Th细胞亚群和细胞因子网络失衡.世界华人消化杂志,2007;15(8):791-799[28]游晶,袁丽芳,陈红英,唐宝璋,王辉.TGF-β1与慢性乙型肝炎的关系.世界华人消化杂志,2007;15(8):869-872[29]游晶,庄林,陈红英,杨海秋,唐宝璋,黄梦玲.乙型肝炎病毒基因型及其临床意义的研究进展.世界华人消化杂志,2007;15(9):921-928[30]王辉,游晶,袁丽芳,陈红英,唐宝璋.辅助性T细胞的研究概况及进展.世界华人消化杂志,2007;15(13):1532-1536[31]游晶,庄林,陈红英,台虹,宋建新,欧阳红梅,唐宝璋,HutchaSriplungVirasakdiChongsuvivatwong,AlanGeater,张一凤,杨海秋,黄俊华.国人慢性HBV携带者HBV复制水平与T细胞亚群变化的关系.世界华人消化杂志,2007;15(35):3722-3727[32]庄林,游晶,陈红英,俞岚,孔雷,唐宝章,黄俊华,袁绍明,HutchaSriplung,VirasakdiChongsuvivatwong,AlanGeater,袁丽芳,王辉.云南地区乙型肝炎病毒基因型分布与临床的相关性.世界华人消化杂志,2007;15(19):2120-2127[33]游晶,庄林,李云丽,陈红英,俞岚,唐宝章,黄梦玲,黄俊华,袁绍明,王辉,袁丽芳.云南汉族慢性乙型肝炎患者HBV基因型及其临床意义.中华微生物学和免疫学杂志,2007;27(6):564[34]陈超,游晶,杨微波,张宏丽,李俊敏,戴虹,张禄,.HIV-1Nef作用机制的研究进展.重庆医学,2012;41(6)[35]黄俊华,游晶.ALT正常的HBV慢性携带者肝组织病理结果分析.临床肝胆病杂志,2007;23(1):6-8[36]庄林,游晶,雷华,李云丽,孔蕾,王晴晴,胡明芬,柏宝.ALT轻度升高HBVDNA水平不同的慢性乙型肝炎患者肝组织学差异探讨.临床肝胆病杂志,2011;27(12):1278-1281,1284近五年来对外学术交流：1．The18thWoncaWorldConference(Wonca2007).July24-27,2007,TheSuntecSingaporeConventionandExhibitionCentre,Singapore.2．The4thHongKong-ShanghaiInternationalLiverCongress(ILC2008)“MolecularTargetinginLiverDisease–FromBenchtoBesides”,12-15June2008,HongKongConvention&ExhibitionCentre,HongKong,China.3．19thConferenceoftheAPASL,2009,HongKong(APASLHongKong2009),13-16February2009,HongKong4．3rdDitanInternationalConferenceonInfectiousDiseases(3rdDICID2009),30July-2Ausust2009,Beijing5．14thInternationalCongressonInfectiousDiseases(ICID),2010,Miami,Florida,USA,9-12March2010,Miami,Florida,USA.6．20thConferenceoftheAPASL,2010,Beijing,25-28March2010,ChinaNationalConventionCentre,Beijing,China.7．4thDitanInternationalConferenceonInfectiousDiseases(DICID),15-18July2010,BeijingInternationalConventionCentre,China8．The61stAnnualMeetingofTheAmericanAssociationfortheStudyofLiverDiseases(AASLD),29October-2November2010,BostonHynesConventionCenter,USA.9．The21thConferenceoftheAPASL,2011,Bangkok,17-20February2011,Bangkok,Thailand.10．5thDitanInternationalConferenceonInfectiousDiseases(DICID),14-18July2011,BeijingInternationalConventionCentre,China11．The62ndAnnualMeetingofTheAmericanAssociationfortheStudyofLiverDiseases(AASLD),November4-8,2011,MosconeWestConventionCenter,SanFrancisco,California,USA