头颈及食道肿瘤

孙艳，女，1962年出生，主任医师，副教授，硕士导师。中国抗癌协会鼻咽癌专业委员会委员。1985年，毕业于天津医科大学医学系，获学士学位。1988年毕业于天津医科大学研究生院放射肿瘤专业获硕士学位,导师杨天恩教授。2000年于德国Freiburg大学放射肿瘤专业获博士学位，导师 Prof.H.Frommhold。1985年以来，一直从事临床、教学和科研工作，发表30余篇科研论文、译文和综述，以及著作。研究题目包括有中药放射增敏的研究，快中子临床应用前相对生物效应(RBE)的研究和临床应用研究等。目前的研究课题包括：头颈鳞癌、食道癌基因不稳定性与临床因素关系的研究;胸部放疗对心脏损伤影响;基因治疗在头颈部肿瘤临床治疗中的研究;放射性龋齿;中晚期头颈部鳞癌、鼻咽癌同期放化疗疗效及毒性作用观察;头颈部肿瘤调强放疗;头颈鳞癌靶向治疗的临床研究。专长：头颈及食道肿瘤Curriculum VitaeYan Sun M.D.Radiation Oncology DepartmentBeijing Cancer HospitalPeking University School of OncologyBeijing 100036, ChinaProfessional position: Chief physician, Associate professor, Graduate teacher，Member of the Society of Nasopharyngeal Carcinoma, Chinese Anti-cancer Association.Telephone number: 88196010Education and Degree:1980-1985 Bachelor of Medicine, Tianjin Medical University1985-1988 Master of Medicine, study and work under the direction of Prof. Yang Tianen in department of radiation oncology, Tianjin Medical University, Major of radiation oncology1998-2000 Doctor of Medicine, study and work under the direction of Prof. H. Frommhold in department of radiation oncology, Freiburg University, Germany, Major of radiation oncologyProfessional experience:1988-1997 Resident doctor and doctor in charge, Department of Radiation Oncology, Beijing Institute for Cancer Research, Beijing Medical University.1997-2004 Associate chief physician, Peking University School of Oncology1998-2000 Study in department of radiation oncology, Freiburg University, Germany2002 Associate Professor, Peking University School of Oncology2004 Chief Physician, Beijing Cancer Hospital, Peking University School of OncologyClinical work and research:Besides conventional clinical and teaching work, clinical research work included now: 1. The study of the relationship between genetic instability in head and neck squamous cell carcinoma and esophagus carcinoma and clinic-pathological factors; 2. Effect of radiation therapy for patients with thoracic tumors on heart; 3. Radiation induced caries; 4. Concomitant radiochemotherapy in advanced HNSCC and nasopharynx carcinoma and side effect evaluation; 5. Study of Generadiotherapy in HNSCC; 6. IMRT in Head and Neck tumors; 7. Clinical study of target therapy in HNSCC.2000年以来发表主要文章目录1. Sun Y, Weissenberger C, Riede R, Henke M, Guttenberger R. Microsatellite Instability in Squamous Cell Carcinoma of the Head and Neck: Association with Loss of Heterozygosity at 10q23. Report. DEGRO'2000, Muenchen, Oct. 2000.2. 孙艳，肖绍文，余荣，张珊文. p53基因变异在食道癌中的意义.青年放射肿瘤科学论坛. 2(2):259-262,2001.3.邓珊明，陈克能，孙艳，王怡，徐光炜. 胸部放射治疗对心血管的影响.中华放射医学与防护杂志. 22(4):307-309,2002.4. 孙艳，邓珊明，陈克能，董一平，韩树奎. 50例恶性胸腺肿瘤放疗对心脏损伤研究.中华放射医学与防护杂志22(6):48-49,2002.5.孙艳,刘立华，张珊文. 宫颈癌的基因学改变和基因治疗. 国外医学肿瘤学分册. 8(12):458-462, 2002.6.孙艳，韩树奎. 应用剂量体积直方图分析恶性胸腺肿瘤放疗对心脏毒性影响. 中华放射医学与防护杂志23(1):35-37,2003.7.孙艳，余荣，刘宝国，马戈，张珊文. 青少年鼻咽癌：综合治疗的意义. 中华临床医学杂志. 2(1):1-4,2003.8. SUN Yan; HAN Shukui; DENG Shanming: Cardiac Toxicity after Radiation Therapy for 52 Patients with Malignant Thymic Tumors. Chinese Journal of Cancer Research 15(3)205:-209,2003.9.张珊文，肖绍文，刘长青，孙艳，苏星，李东明，徐刚，蔡勇，朱广迎，徐博，吕有勇. 重组人p53腺病毒注射液联合放射线治疗头颈鳞癌的II期临床试验. 中华医学杂志. 83(23):2023-2028,2003.10.孙艳. 头颈部鳞癌的放化疗. 北京放射肿瘤学术论坛. 5(1):12-17,2004.11.S.ZHANG, G.XU, C.LIU, S.XIAN, Y.SUN, X.SU, Y.CAI, D.LI,&B.XU. Clinical study of recombinant adenovirus-p53 (Adp53) combined with hyperthermia in advanced cancer. Int. J. Hyperthermia, 21(7):631-636,2005.12. Sun Y. Clinical study of adenoviral mediated p53 gene therapy for advanced head and neck tumors. C8-9. Report. ISCGT'2005, Shenzhen,China, December 2005.13.郑宝敏，孙艳.放射性龋齿相关因素研究. 国外医学临床放射学分册 29(4):280-284,2006.14. Y Sun. Clinical outcome of combination of adenoviral mediated p53 gene with radiotherapy for advanced cancers in head and neck. O-37. Report. ISCGT'2006, Chiba, Japan, October 2006.15.孙艳，郑宝敏，吴昊，韩树奎，徐博，朱广迎，张珊文. 局部进展期鼻咽癌同期调强放化疗I期临床观察.中华放射医学与防护杂志.(in press) 2007.

发表30余篇科研论文、译文和综述，以及著作。

1. Sun Y, Weissenberger C, Riede R, Henke M, Guttenberger R. Microsatellite Instability in Squamous Cell Carcinoma of the Head and Neck: Association with Loss of Heterozygosity at 10q23. Report. DEGRO'2000, Muenchen, Oct. 2000.

2. 孙艳，肖绍文，余荣，张珊文. p53基因变异在食道癌中的意义.青年放射肿瘤科学论坛. 2(2):259-262,2001.

3.邓珊明，陈克能，孙艳，王怡，徐光炜. 胸部放射治疗对心血管的影响.中华放射医学与防护杂志. 22(4):307-309,2002.

4. 孙艳，邓珊明，陈克能，董一平，韩树奎. 50例恶性胸腺肿瘤放疗对心脏损伤研究.中华放射医学与防护杂志22(6):48-49,2002.

5.孙艳,刘立华，张珊文. 宫颈癌的基因学改变和基因治疗. 国外医学肿瘤学分册. 8(12):458-462, 2002.

6.孙艳，韩树奎. 应用剂量体积直方图分析恶性胸腺肿瘤放疗对心脏毒性影响. 中华放射医学与防护杂志23(1):35-37,2003.

7.孙艳，余荣，刘宝国，马戈，张珊文. 青少年鼻咽癌：综合治疗的意义. 中华临床医学杂志. 2(1):1-4,2003.

8. SUN Yan; HAN Shukui; DENG Shanming: Cardiac Toxicity after Radiation Therapy for 52 Patients with Malignant Thymic Tumors. Chinese Journal of Cancer Research 15(3)205:-209,2003.

9.张珊文，肖绍文，刘长青，孙艳，苏星，李东明，徐刚，蔡勇，朱广迎，徐博，吕有勇. 重组人p53腺病毒注射液联合放射线治疗头颈鳞癌的II期临床试验. 中华医学杂志. 83(23):2023-2028,2003.

10.孙艳. 头颈部鳞癌的放化疗. 北京放射肿瘤学术论坛. 5(1):12-17,2004.

11.S.ZHANG, G.XU, C.LIU, S.XIAN, Y.SUN, X.SU, Y.CAI, D.LI,&B.XU. Clinical study of recombinant adenovirus-p53 (Adp53) combined with hyperthermia in advanced cancer. Int. J. Hyperthermia, 21(7):631-636,2005.

12. Sun Y. Clinical study of adenoviral mediated p53 gene therapy for advanced head and neck tumors. C8-9. Report. ISCGT'2005, Shenzhen,China, December 2005.

13.郑宝敏，孙艳.放射性龋齿相关因素研究. 国外医学临床放射学分册 29(4):280-284,2006.

14. Y Sun. Clinical outcome of combination of adenoviral mediated p53 gene with radiotherapy for advanced cancers in head and neck. O-37. Report. ISCGT'2006, Chiba, Japan, October 2006.

15.孙艳，郑宝敏，吴昊，韩树奎，徐博，朱广迎，张珊文. 局部进展期鼻咽癌同期调强放化疗I期临床观察.中华放射医学与防护杂志.(in press) 2007.

中国抗癌协会鼻咽癌专业委员会委员。

自1985年以来，一直从事放射肿瘤专业的临床与教学和科研工作。以第一作者在国内外发表论文及综述等27篇。目前进行的研究课题有：头颈鳞癌、食道癌基因不稳定性与临床因素关系的研究（与德国Freiburg大学合作交流）；青少年鼻咽癌的综合治疗；胸部放疗对心脏损伤影响