常见精神疾病，特别是抑郁症、焦虑症、双相情感障碍的诊断与治疗

医学博士，副主任医师，首都医科大学精神卫生学系讲师。任职国家精神心理疾病临床医学研究中心，主要研究方向为心境障碍的诊断、评估与治疗。　　2015年6月-2016年6月、2017年10月-2018年1月在美国纽约范士丹医学研究所和澳门大学访学。以第一作者或通讯作者发表在国内外专业领域期刊发表文章30余篇，其中一作SCI论文14篇。作为课题负责人，获批国家自然科学1项，省部级项目1项，市局级项目2项。作为课题骨干，参与科技部支撑项目、国家自然科学基金、973项目等10项。2016年获得北京市科学技术委员会颁发的首都十大疾病科技攻关“创新型”重大科技进展奖。2016年获得北京市医院管理局培育计划项目资助，2017年获得北京市科学技术委员会首都临床特色应用研究与成果推广项目资助。2018年获得中华医学科技奖三等奖。　　在国内首次开展低场强磁刺激技术(Low-field magnetic stimulation)治疗了抑郁症和双相抑郁的临床研究，并在领域发表相关学术论文4篇。自2006年以来，作为项目协调员和研究者，参与多项新药Ⅰ至Ⅳ期临床试验30余项，并参与临床试验报告撰写与发表，掌握常见精神科药物的疗效机制。      学术任职    中华医学会精神病学分会青年委员。   主研方向   抑郁症、双相障碍的临床诊疗    学术论著  　　[1] Xiao L, Zhu X, Gillespie A, Feng Y, Zhou JJ, Chen X, Gao Y, Wang X, Ma X, Gao C, Xie Y, Pan X, Bai 7, Xu X, Wang G, Chen R. Effectiveness of mirtazapine as add-on to paroxetine v. paroxetine or mirtazapine monotherapy in patients with major depressive disorder with early non-response toparoxetine: a two-phase, multicentre, randomized, double-blind clinical trial. Psychological Medicine, 2020. 1–9. https://doi.org/10.1017/S0033291719004069　　[2] Zheng W#, Li W#, Qi H#, Xiao L#, Sim K, Ungvari GS, Lu X-B, Huang X, Ning Y-P*, Xiang Y-T*. Adjunctive folate for major mental disorders: A systematic review. Journal of Affective Disorders 2020;267:123-130.　　[3] Xiao L, Zhou J, Feng Y, Zhu X, Wu W; Hu Y, Niu Y, Hu J, Wang X, Gao C, Zhang N, Fang Y, Liu T, Jia F, Feng L*, Wang G* Does early and late life depression differ in residual symptoms, functioning and quality of life among the first-episode major depressive patients. Asian Journal of Psychiatry, 2019 Oct 16;47:101843. doi: 10.1016/j.ajp.2019.101843.　　[4] Feng Y#, Xiao L#, Wang WW, Ungvari GS, Ng CH, Wang G, Xiang YT. Guidelines for the diagnosis and treatment of depressive disorders in China: The second edition. Journal of affective disorders. 2019 May 1;253:352-356.　　[5] Xiao L, Feng L, Zhu XQ, Feng Y, Wu WY, Ungvari GS, Ng CH, Xiang YT, Wang G: Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study. Psychiatry research 2018, 261:547-553.　　[6] Xiao L, Correll CU, Feng L, Xiang YT, Feng Y, Hu CQ, Li R, Wang G: Rhythmic Low-field magnetic stimulation may improve depression by increasing brain derived neurotropic factor. CNS Spectrums 2018:1-9.　　[7] Wang YY#, Xiao L#, Rao WW#, Chai JX#, Zhang SF, Ng CH, Ungvari GS, Zhu H, Xiang YT: The prevalence of depressive symptoms in 'left-behind children' in China: a meta-analysis of comparative studies and epidemiological surveys. Journal of affective disorders 2019, 244:209-216.　　[8] Xiao L; Stephen Ganocy; Robert Findling; Kiki Chang; Melissa DelBello; John Kane; Mauricio Tohen; Yu-Tao Xiang; Christoph Correll. Baseline characteristics and early response at week 1 predict treatment outcome in adolescents with bipolar manic or mixed episode treated with olanzapine: Results from a 3-week, randomized, placebo-controlled trial.2017. The Journal of Clinical Psychiatry. 2017,78(9):e1158-e1166.　　[9] Guo T#, Xiang YT#, Xiao L#, Hu CQ#, Chiu HF, Ungvari GS, Correll CU, Lai KY, Feng L, Geng Y, Feng Y, Wang G. Measurement-Based Care Versus Standard Care for Major Depression: A Randomized Controlled Trial With Blind Raters. Am J Psychiatry.2015 Oct;172(10):1004-13.　　[10] Xiao L, Tang YL, Smith AK, Xiang YT, Sheng LX, Chi Y, Du WJ, Guo S, Jiang ZN, Zhang GF, Luo XN. Nocturnal sleep architecture disturbances in early methadone treatment patients. Psychiatry Res. 2010 Aug 30;179(1):91-5.　　[11] Cui S, Li Y, Xiang YT, Yan KJ, Fan C, Chen Q, Du W, Zhang G, Xiao L, Li Y,Yuan X, Xie K, Luo X. Demographic and Clinical Features of Chinese Heroin Users Who Switch from Non-injection to Injection. Subst Use Misuse. 2015;50(14):1739-46.　　[12] Liu J, Xiang YT, Lei H, Wang Q, Wang G, Ungvari GS, Morris DW, Zhu XZ, Lai KY, Zhong BL, Wong SY, Zhang L, Zhang Q, Zou YC, Xiao L, Zhao Q, Li Y, Wu J, Zhang GF, Chiu HF. Guidance on the conversion of the Chinese versions of the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR) and the Montgomery-Asberg Scale (C-MADRS) in Chinese patients with major depression. J Affect Disord. 2014 Jan;152-154:530-3.　　[13] Liu J, Xiang YT, Wang G, Zhu XZ, Ungvari GS, Kilbourne AM, Lai KY, Zhong BL,Zhang L, Zhang Q, Zou YC, Xiao L, Zhao Q, Li Y, Wu J, Zhang GF, Chiu HF. Psychometric properties of the Chinese versions of the Quick Inventory of Depressive Symptomatology - Clinician Rating (C-QIDS-C) and Self-Report(C-QIDS-SR). J Affect Disord. 2013 May;147(1-3):421-4.　　[14] Zhang GF, Tang YL, Smith AK, Liu ZQ, Sheng LX, Chi Y, Du WJ, Guo S, Jiang ZN, Xiao L, Zhang HX, Luo XN. Alterations in pituitary-thyroid axis function among opioid-dependent subjects after acute and protracted abstinence. Addict Biol.2009 Jul;14(3):310-4.　　[15] Zhang GF, Ren YP, Sheng LX, Chi Y, Du WJ, Guo S, Jiang ZN, Xiao L, Luo XN,Tang YL, Smith AK, Liu ZQ, Zhang HX. Dysfunction of the hypothalamic-pituitary-adrenal axis in opioid dependent subjects: effects of acute and protracted abstinence. Am J Drug Alcohol Abuse. 2008;34(6):760-8.　　[16] 肖乐, 丰雷, 王刚. 低场强磁刺激技术在神经精神疾病治疗中的应用与展望 [J] . 中华精神科杂志,2018,51( 3 ): 201-203.　　[17] 肖乐, 丰雷, 朱雪泉,等. 中国抑郁症患者急性期治疗后残留症状的现况调查[J]. 中华精神科杂志, 2017, 50(3):175-181.　　[18] 肖乐,袁晓菲,阎锴娟,崔少娟,李亚琼,张国富,陈群,罗小年. 长期吸食甲基苯丙胺对决策功能的影响[J]. 临床精神医学杂志,2016,2:112-114.　　[19] 肖乐,冯媛,丰雷,胡昌清,张国富,王刚. 深部经颅磁刺激对难治性抑郁症患者的疗效及对血清脑源性神经营养因子的影响[J]. 临床精神医学杂志,2015,6:361-364.　　[20] 肖乐,任艳萍,张国富,罗小年. 海洛因依赖者多导睡眠图与主观评估对比分析[J]. 临床精神医学杂志,2009,6:364-366.　　[21] 肖乐,张国富,任艳萍,盛利霞,迟勇,杜万君,姜佐宁,汤宜朗,郭松,罗小年. 海洛因依赖者美沙酮替代治疗早期的多导睡眠图研究[J]. 中国神经精神疾病杂志,2007,12:706-710.