苏培强

医疗特长：苏教授从事骨科临床工作 20 余年，主要致力于颈椎病，腰椎间盘突出症，青少年特发性脊柱侧凸、遗传性骨骼畸形等常见运动系统疾病的机制与临床诊治相关研究，同时擅长常规颈椎病/腰椎病的最优化治疗，擅长脊柱截骨矫形术、脊柱肿瘤完整切除、后路寰枢椎椎弓根钉固定及植骨融合术。2015年曾接诊一名严重神经肌肉性脊柱侧凸合并呼吸功能受限，用力肺活量（FVC）仅为18%，属于手术的绝对禁忌症。此例患者为我国首例，苏教授经过术前头环牵引及呼吸锻炼的方法，为患者施行了手术，使患者的侧凸得到了良好的纠正及呼吸功能得到了明显的增强，同时建立了该类疾病的围手术期治疗流程。苏教授十多年来收集了大量遗传性骨病的标本资源，围绕骨骼系统畸形和退变性疾病的遗传发病机制，开展了从定位基因、构建动物模型到功能分析的系列研究，形成了科学的理论体系并运用于临床优生优育，同时将精准医学理念运用于临床骨科领域。研究方向：运动系统发育畸形与基因调控主要教育和工作经历：1993.09-1998.07 中山医科大学 临床医学 学士学位2000.09-2003.07 中山大学 外科学 硕士学位，导师：黄东生2005.09-2008.07 中山大学 骨科学 博士学位，导师：刘尚礼1998.07-2000.08深圳沙井人民医院 住院医师2003.07-2009.12  中山大学附属第二医院 住院医师-主治医师2005.07-2005.09  香港中文大学威尔斯亲王医院 进修临床医师2009.12-2013.12  中山大学附属第一医院 副教授/副主任医师2011.03-2013.02  美国德州大学西南医学研究中心 联合博士后培训2013.12-至今  中山大学附属第一医院 研究员2016.12-至今  中山大学附属第一医院 研究员/主任医师2017.12-至今  中山大学附属第一医院 研究员/主任医师/教授社会兼职：国际脊柱遗传、发育和疾病研究协会（ICSGDD）  委员国际矫形与创伤外科学会基础专业委员会 常务委员中国康复医学会脊柱脊髓基础研究学组  委员中华医学会骨科学分会基础学组 委员中华医学会骨科学分会创新与转化学组  委员广东医学会脊柱外科分会委员兼脊柱畸形学组  副组长论著：Peiqiang Su，Ruofan Ma, ChunhaiLi, Shangli Liu, Dongsheng Huang(*).Pedicle screw fixation of the cervical spine: guidance by computed tomography. Clinicalorthopaedics and related research.2007Sep;462:99-104.Peiqiang Su（#）, Ru Li(#), ShangliLiu, Yan Zhou, Xinguang Wang, Nilesh Patil, Christopher S. Mow, Justin C. Mason,Dongsheng Huang(*), Yiming Wang(*). Age at onset-dependent presentations ofpremature hip osteoarthritis, avascular necrosis of the femoral head, orLegg-Calvé-Perthes disease in a single family, consequent upon a p.Gly1170Sermutation of COL2A1.Arthritis Rheumatism.2008 Jun;58(6):1701-6.Peiqiang Su（#）, Liangming Zhang（#）, Yan Peng, Anjing Liang, Kaili Du, Dongsheng Huang(*). Ahistological and ultrastructural study of femoral head cartilage in a new typeII collagenopathy. InternationalOrthopaedics (SICOT).2010 Dec;34(8):1333-9.Liangming Zhang（#）, Peiqiang Su（#）, Caixia Xu, JunlinYang, Weihua Yu, Dongsheng Huang(*). Chondrogenic differentiation ofhuman mesenchymal stem cells: a comparison between micromass and pellet culturesystems.Biotechnol Lett. 2010Sep;32(9):1339-46.Caixia Xu, PeiqiangSu, Yingjun Wang, Xiaofeng Chen, Yongchun Meng, Chang Liu, Xinbing Yu,Xuhui Yang, Weihua Yu, Xiuming Zhang, Andy Peng Xiang(*). A novel biomimeticcomposite scaffold hybridized with mesenchymal stem cells in repair of rat bonedefects models. Journal Of Biomedical MaterialsResearch A. 2010 Nov;95(2):495-503.Liangming Zhang, PeiqiangSu（*）, Caixia Xu,Changhua Chen, Anjing Liang, Kaili Du,Yan Peng, Dongsheng Huang(*).Melatonin inhibits adipogenesis and enhancesosteogenesis of human mesenchymal stem cells by suppressing PPARγ expressionand enhancing Runx2 expression. JournalOf Pineal Research.2010 Nov;49(4):364-72Caixia Xu, PeiqiangSu, Xiaofeng Chen, Yongchun Meng, Weihua Yu, Andy Peng Xiang, Yingjun Wang(*).Biocompatibility and osteogenesis of biomimeticBioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissueengineering.Biomaterials. 2011 Feb;32(4):1051-8Yuanyuan Pei, Yiming Wang, Weijun Huang, Bin Hu,Dongsheng Huang, Yan Zhou, Peiqiang Su(*).Novelmutations of EXT1 and EXT2 genes among families and sporadic cases withmultiple exostoses. Genetic Testing andMolecular Biomarkers. 2010 Dec;14(6):865-72.Peiqiang Su（#）, Hongke Ding（#）, Dongsheng Huang, Yan Zhou, Weijun Huang, Liangying Zhong, Tim J Vyse,Yiming Wang（*）. A 4.6 kb genomic duplication on 20p12.2-12.3 is associated with brachydactylytype A2 in a Chinese family. J MedGenet. 2011 May;48(5):312-6.Dongsheng Huang, Kaili Du, Shingxing Zeng, Wenjie Gao,Lingzhi Huang, Peiqiang Su (*). Thesecurity analysis of transpedicular screw fixation in the lower cervical spineand a case report. Spine (Phila Pa1976). 2011 Dec 15;36(26):E1702-8.Peiqiang Su（#）, Wentong Zhang（#）, Yan Peng, Anjing Liang, Kaili Du, Dongsheng Huang（*）. Use of computed tomographic reconstruction to establishthe ideal entry point for pedicle screws in idiopathic scoliosis. European Spine Journal. 2012 Jan;21(1):23-30.Yan Peng（#）, Guoyan Liang（#）, Yuanyuan Pei, Wei Ye, Anjing Liang,Peiqiang Su (*). Genomic polymorphisms of G-Protein Estrogen Receptor 1 areassociated with severity of adolescent idiopathic scoliosis. International Orthopaedics (SICOT) .2012Mar;36(3):671-7Guoyan Liang（#）, Wenjie Gao（#）, Anjing Liang, Wei Ye,Yan Peng, Liangming Zhang, Swarkar Sharm, Peiqiang Su (*), Dongsheng Huang（*）.Normal leptin expression, lower adipogenic ability,decreased leptin receptor and hyposensitivity to leptin in adolescent idiopathicscoliosis. PLoS One. 2012,7(5):e36648.Liangming Zhang（#）, Jinling Zhang（#）, You Ling, Changhua Chen, Anjing Liang,Yan Peng, Hong Chang, Peiqiang Su (*), Dongsheng Huang（*）. Sustained release of melatonin from poly(lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of humanmesenchymal stem cells in vitro. JournalOf Pineal Research. 2013,54:24–32.Wenjie Gao（#）, Yan Peng（#）, Guoyan Liang, Anjing Liang, Wei Ye, Liangming Zhang, Swarkar Sharma, Peiqiang Su(*), Dongsheng Huang（*）. Association between Common Variants near LBX1 andAdolescent Idiopathic Scoliosis Replicated in the Chinese Han Population. PLoS One. 2013, 8(1): e53234. Wenjie Gao（#）, Mianlong Lin（#）, Anjing Liang（#）, Liangming Zhang,Changhua Chen, Guoyan Liang, Caixia Xu, Yan Peng,ChongChen, Dongsheng Huang（*）, Peiqiang Su (*). Melatonin enhances chondrogenicdifferentiation of human mesenchymal stem cells. Journal Of Pineal Research. 2014, 56(1):62-70. Guoyan Liang（#）, Chengjie Lian（#）, Di Huang, Wenjie Gao, Anjing Liang, Yan Peng, Wei Ye, Zizhao Wu, Peiqiang Su（*）,Dongsheng Huang（*）. Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis CascadeCauses Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model. PLoS One. 2014,9(1):e86894.Ye Wang（#）, Peiqiang Su（#）, Bin Hu（#）, Wenjuan Zhu（#）, Qibin Li, Ping Yuan, Jiangchao Li, Xinyuan Guan, Fucheng Li, XiangyiJing, Ru Li, Yongling Zhang, Claude Férec, David N. Cooper, Jun Wang, DongshengHuang（*）, Jian-Min Chen（*）, Yiming Wang（*）. Characterization of 26 deletion CNVs reveals the frequent occurrence ofmicro-mutations within the breakpoint-flanking regions and frequent repair ofdouble-strand breaks by templated insertions derived from remote genomicregions. Human Genetics; June 2015,Volume 134, Issue 6, pp 589-603.Peiqiang Su (#), Ye Wang（#）, David N. Cooper, Wenjuan Zhu, Dongsheng Huang, ClaudeFérec, Yiming Wang, Jian-Min Chen（*）. Disclosing the Hidden Structure and Underlying Mutational Mechanism of aNovel Type of Duplication CNV Responsible for Hereditary Multiple Osteochondromas.Human Mutation; 2015Aug;36(8):758-63. Chengjie Lian（#）,Zizhao Wu（#）,Bo Gao（#）,Yan Peng,Anjing Liang,Caixia Xu,Lei Liu,XianjianQiu,Junjun Huang,HangZhou,Yifeng Cai, Peiqiang Su (*), Dongsheng Huang（*）.Melatonin reversed tumor necrosis factor- alpha- inhibitedosteogenesis of human mesenchymal stem cells bystabilizing SMAD1 protein. Journal Of Pineal Research. 2016Oct;61(3):317-27. Yifeng Cai ,Jiaquan Luo ,Junjun Huang,Chengjie Lian, HangZhou,Hao Yao, Peiqiang Su (*).Interspinous spacers versus posteriorlumbar interbody fusion for degenerative lumbar spinal diseases: ameta-analysis of prospective studies.InternationalOrthopaedics (SICOT) 2016 Jun;40(6):1135-42Chong Chen（#）, Caixia Xu（#）, Taifeng Zhou, Bo Gao, Hang Zhou, Changhua Chen, Changli Zhang, Dongshen Huang（*）, Peiqiang Su (*). Abnormal osteogenic andchondrogenic differentiation of human mesenchymal stem cells from patients withadolescent idiopathic scoliosis in response to melatonin.Molecular medicine reports. 2016 Aug;14(2):1201-9. Bo Gao, Wenjie Gao, Chong Chen, Qinghua Wang, ShaochunLin, Caixia Xu, Dongsheng Huang,Peiqiang Su(*)What is the Difference in Morphologic Features of the ThoracicPedicle Between Patients With Adolescent Idiopathic Scoliosis and HealthySubjects? A CT-based Case-control Study. ClinicalOrthopaedics and Related Research.2017 Nov;475(11):2765-2774.Wenjie Gao（#）, Chong Chen（#）, Taifeng Zhou（#）, Shulan Yang, Bo Gao, Hang Zhou, Chengjie Lian, Zizhao Wu, Xianjian Qiu,Xiaoming Yang, Esam Alattar, Wentao Liu, Deying Su, Silong Sun, Yulan Chen,Kenneth M. C. Cheung, Youqiang Song, Keith K. D. Luk, Danny Chan, Pak ChungSham, Chao Xing, Chiea Chuen Khor, Gabriel Liu, Junlin Yang, Yubin Deng,Dingjun Hao, Dongsheng Huang, Quan-Zhen Li, Caixia Xu（*）, Peiqiang Su (*).Rare coding variants in MAPK7 predispose to adolescentidiopathic scoliosis. Human Mutation.2017 Nov;38(11):1500-1510. Chengjie Lian（#）, Bo Gao（#）, Zizhao Wu, Xianjian Qiu, Yan Peng, Anjing Liang, Caixia Xu（*）, Peiqiang Su(*), Dongsheng Huang.Collagen type II is downregulated in thedegenerative nucleus pulposus and contributes to the degeneration and apoptosisof human nucleus pulposus cells. Mol MedRep. 2017 Oct;16(4):4730-4736. Kai Han（#）, Yongqian Wang（#）, Shangbin Cui, Caixia Xu（*）, Peiqiang Su (*), Successfulsurgery for a neuromuscular scoliosis patient by pulmonary rehabilitation withforced vital capacity below 30%. European SpineJournal. 2018 Jan 16.[Epubahead of print]Taifeng Zhou（#）, Yongqian Wang（#）, Hang Zhou（#）, Zhiheng Liao, Bo Gao, Deying Su, Shuhui Zheng,Caixia Xu(*), Peiqiang Su (*). Dual novelmutations in SLC26A2 in two siblings with multiple epiphyseal dysplasia 4 froma Chinese family: a case report. BMC Medical Genetics.2018May 3;19(1):70.Bo Gao（#）, Wenjie Gao（#）, Zizhao Wu（#）, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, AnjingLiang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su (*), Dongsheng Huang(*). Melatonin rescuedinterleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. StemCell Research & Therapy.2018 Jun 14;9(1):162.Taifeng Zhou（#）,Chong Chen（#）,Caixia Xu（#）,Hang Zhou,Bo Gao,Deying Su,Zhiheng Liao,Yongyong Li,Shulan Yang, Peiqiang Su (*),Mutant MAPK7-Induced Idiopathic Scoliosis is Linkedto Impaired Osteogenesis. Cellular Physiology and Biochemistry. 2018 Jul20;48(3):880-890Zizhao Wu（#）, Xianjian Qiu（#）, Bo Gao（#）, Chengjie Lian, Yan Peng,Anjing Liang, Caixia Xu, WenjieGao, Liangming Zhang, Peiqiang Su, Limin Rong(*), Dongsheng Huang(*).Melatonin-mediatedmiR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation ofhuman mesenchymal stem cells.Journal Of Pineal Research. 2018 Aug;65(1):e12483.Shuhui Zheng（#），Hang Zhou（#），Zhuohui Chen, Yongyong Li, Taifeng Zhou, Chengjie Lian,Bo Gao, Peiqiang Su（*），Caixia Xu(*). TypeIII Transforming Growth Factor-β Receptor RNA Interference (RNAi) Enhances TGF-β3-inducedChondrogenesis Signaling in Human Mesenchymal Stem Cells. Stem Cells Internation. 2018; 2018: 4180857.Shuhui Zheng（#），Hang Zhou（#），Bo Gao,YongyongLi, Zhiheng Liao, Taifeng Zhou, Chengjie Lian, Zizhao Wu, DeyingSu, Tingting Wang，Peiqiang Su(*)，CaixiaXu(*). Estrogen promotes the onset and development of idiopathic scoliosis viadisproportionate endochondral ossification of the anterior and posterior columnin a bipedal rat model. Experimental& Molecular Medicine. 2018 Nov; 50(11): 144.其他主要工作成绩（比如获奖情况）：1、X基因突变引起特发性脊柱侧凸的发生--COA赵以甦骨科基础奖二等奖 2014年2、中山大学实习医生临床技能大赛--"教官组"特等奖 2013年3、股骨颈骨折外科治疗的基础与临床研究--广州市科技进步二等奖2008年（第八名） 4、新技术治疗退变性腰椎间盘病的基础与临床研究--广东省科技进步二等奖2006年（第七名）??

1.新技术治疗退变性腰椎间盘病的基础与临床研究--广东省科技进步二等奖2006 (7)

2. 新技术治疗脊柱侧凸的基础与临床研究--广州市科技进步二等奖2003 (10)

3.广东省南粤优秀研究生 2003年

4.股骨颈骨折外科治疗的基础与临床研究--广州市科技进步二等奖2008 (6)

Peiqiang Su, Shangli Liu, Dongsheng Huang. Age at Onset–Dependent Presentations of Premature Hip Osteoarthritis, Avascular Necrosis of the Femoral Head, or Legg-Calve´-Perthes Disease in a Single Family, Consequent Upon a p.Gly1170Ser Mutation of COL2A1 ARTHRITIS & RHEUMATISM. 58(6)2008：1701–1706 (SCI 影响因子7.75)

Peiqiang Su, Ruofan Ma, Shangli Liu, et al. Pedicle Screw Fixation of the Cervical Spine：Guidance by Computed Tomography. clinical orthopaedics and related research 2007，462：99-104 (SCI 影响因子2.16)

社会学术团体兼职情况：

广东省医学会脊柱外科分会委员兼秘书

广东省骨关节与风湿康复学会委员

以第一负责人承担的课题:(校内外经费共约150万)

1.青少年特发性脊柱侧凸易感基因的多阶段研究--国家自然科学基金(2008年-2010年，30700456 )24万

2.基因改变与椎间盘退变相关关系研究--广东省自然科学基金 (2006年-2008年，5001754) 4

3.TGF-b与IGF-1多态性与椎间盘退变的关系研究--广东省医学科学基金(2006年-2008年，B2005033)0.5万

4.椎间盘退变性疾病外科治疗的前瞻性研究--广东省社会发展计划基金(2007年-2009年) 7万

5.青少年特发性脊柱侧凸数据库的建立与基因研究--教育部大学生创新计划基金 (2008年-2010年) 1万

6.遗传性股骨头病变动物模型的建立及发病机理研究--广东省自然科学基金(2009年-2011年，8151008901000141)6万

9.椎间盘退变中的干细胞调节--教育部大学生创新计划基金(2009年-2011年) 1万

以第二、三主要负责人承担的课题经费约300万