卜军

卜军教授，上海交通大学医学院附属仁济医院心内科（国家临床重点专科、国家教育部211重点学科）科主任、主任医师、博导，科技部中青年科技创新领军人才（2017年）、国家杰出青年基金获得者（2016年）、教育部长江学者特聘教授（2016年）、教育部新世纪优秀人才（2012年），美国心脏协会专家会员(FAHA)、美国心脏病学会专家会员(FACC)、欧洲心脏病学会专家会员(FESC)，国家重点研发专项首席专家、上海高水平地方高校重点创新团队负责人，研究成果发表在Circulation、JACC、EHJ、Hepatology、Nat Commun等国际知名期刊，总引用1000余次，写入国际心血管内科学教科书等行业规范，是TCT、CRT、EuroPCR、EuroCHORUS和TCT-AP等国际心血管大会的国际主席团成员，先后获 “吴孟超医学青年奖”、“树兰医学青年奖”、“上海市优秀学科带头人”、“上海市曙光学者”、上海市“明治生命科学奖”等。

科研项目：

1. 国家重点研发专项，编号2018YFC1312800、“心脑血管疾病`协防共管’创新健康管理模式的开发与效果评价”、2018/09-2020/12、1534万元、在研、项目总负责人及首席科学家。


2. 国家杰出青年基金,编号81625002、“心血管内科学 (冠心病事件链机制及干预)”、2017/01-2020/12、350万元、在研、主持。


3. 上海市科委优秀学术带头人计划，编号18XD1402400、“生物钟核受体NR1F1在急性心梗心肌组织水平灌注不良中的关键保护作用”、2018/05-2021/4、40万元、在研、主持。


4. 上海市申康临床创新行动计划项目，编号16CR3034A、“基于三维定量心肌微循环功能的血流储备评估新技术的建立与应用”、2016/12-2019/06、50万元、在研、主持。


5. 上海市教委高峰高原人才项目，编号20152209、“以TMPFC为核心的新型急性心肌死心肌组织水平再灌注临床技术的建立与优化应用”、2015/01-2017/12、100万元、结题、主持。


6. 国家自然科学基金面上项目，编号81470389、“核受体FXR-SHP级联通路参与心肌细胞肥大与心肌成纤维细胞增殖的双重调控及其分子机制”、2015/01- 2018/12、75万元、在研、主持。


7. 国家自然科学基金重点项目，编号81330006、“核受体LXRα/LXRβ差异性SUMO化修饰在心肌梗死后心肌组织重构中的关键作用”、 2014/01-2018/12，290万元、在研、参与（排名第二）。


8. 上海市科委基础研究重点项目，编号14JC1404500 , “肝X受体不同亚型在急性心肌梗死及其后续心肌重构与功能重建中的靶点作用及其关键调控机制”、2014/01-2016/12 ，50万元、已结题、主持。


9. 国家自然科学基金面上项目，编号81270282、“FXR受体通过线粒体途径诱导心肌缺血再灌注损伤的新机制：孤儿受体SHP的关键作用”、2013/01-2016/12、70万元、已结题、主持。


10. 国家教育部新世纪优秀人才计划，编号 NCET-12-0352、“RAR相关孤儿受体在动脉粥样硬化斑块稳定性中的作用及其机制 ”、 2013/01-2015/12 ，50万元、已结题、主持。


11. 上海市曙光计划人才项目，编号12SG-22，“视黄酸相关受体ROR：调控动脉粥样硬化斑块稳定性的新靶点”、2013/01-2015/12，15万元、已结题、主持。


12. 上海市科委国际合作课题，编号12410708300，“急性心肌梗死心肌组织水平灌注的新型评估技术体系建立与优化应用”、2012/01¬-2014/12，25万元、已结题、主持。


13. 国家自然科学基金面上项目，编号81070176、“缺血心肌再灌注及梗死后重塑过程中视黄醛X受体与NR4A1孤核受体通路在线粒体水平的交叉对话及机制”、2011/01-2013/12，32万元、已结题、主持。


14. 上海市教委高校选拔优青专项基金，编号:JDY06034，“RXR核受体：新的抗心力衰竭的药物靶点”、 2007/1-2009/12、10万元、已结题、主持。


15. 国家自然科学基金青年基金，编号30600242、“独特的RXR受体 /Nur77受体信号通路参与心肌肥厚和凋亡的双重调控的分子机制研究”、2007/01-2009/12，23万元、已结题、主持。

科研论文：

1.    Zhao Y, Gao L, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Wang F, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease. Hepatology. 2018. doi: 10.1002/hep.29889 [Epub ahead of print]

2.    Wang XH, Li Z, Mao JL, Zang MH, Pu J*. Low voltage areas in paroxysmal atrial fibrillation: The prevalence, risk factors and impact on the effectiveness of catheter ablation. Int J Cardiol. 2018: S0167-5273(18)33797-5.

3.    Fu Y, Jiang W, Zhao Y, Huang Y, Zhang H, Wang H, Pu J*.  Simple and Efficient Method for In Vivo Cardiac-specific Gene Manipulation by Intramyocardial Injection in Mice. J Vis Exp. 2018;(134). doi: 10.3791/57074

4.    He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J*. The Nuclear Melatonin Receptor RORα Is a Novel Endogenous Defender Against Myocardial Ischemia/Reperfusion Injury. J Pineal Res. 2016;60(3):313-26.

5.    He B, Ding S, Qiao Z, Gao L, Wang W, Ge H, Shen X, Pu J*. Influence of Microvascular Dysfunction on Regional Myocardial Deformation Post-acute Myocardial Infarction: Insights from a Novel Angiographic Index for Assessing Myocardial Tissue-Level Reperfusion. Int J Cardiovasc Imaging. 2016;32(5):711-9.

6.    He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J *. Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy. Hypertension. 2016;67(6):1237-48.

7.    Jiang Y, Bai J, Tang L, Zhang P, Pu J*. Anti-CCL21 Antibody Attenuates Infarct Size and Improves Cardiac Remodeling After Myocardial Infarction. Cell Physiol Biochem.2015;37(3):979-90.

8.    He Q, Pu J*, Yuan A, Yao T, Ying X, Zhao Y, Xu L, Tong H, He B. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol, 2014;13(1): 149.

9.    Guo Q, Wu LM, Wang Z, Shen JY, Su X, Wang CQ, Gong XR, Yan QR, He Q, Zhang W, Xu JR*, Jiang M*, Pu J*. Early Detection of Silent Myocardial Impairment in Patients with New Onset Drug-Naïve Systemic Lupus Erythematosus - A Three-Center Prospective Study (Myocardial Impairment in New Onset SLE). Arthritis Rheumatol. 2018 Aug 2. doi: 10.1002/art.40671. [Epub ahead of print]

10.  Bu Z, Ma J, Fan Y, Qiao Z, Kang Y, Zheng Y, Wang W, Du Y, Zheng Z, Shen X, He B*, Pu J*. Ascending Aortic Strain Analysis Using 2-Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris. J Am Heart Assoc. 2018;7(14).  

11.  Gao L, Zhao Y, He J, Yan Y, Xu L, Lin N, Ji Q, Tong R, Fu Y, Gao Y, Su Y, Yuan A, He B*, Pu J*. The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury. J Genet Genomics. 2018;45(3):125-35.

12.  Huang D, Muramatsu T, Li Y, Yang W, Nagahara Y, Chu M, Kitslaar P, Sarai M, Ozaki Y, Chatzizisis YS, Yan F, Reiber JHC, Wu R*, Pu J*, Tu S. Assessment of endothelial shear stress in patients with mild or intermediate coronary stenoses using coronary computed tomography angiography: comparison with invasive coronary angiography. Int J Cardiovasc Imaging. 2017;33(7):1101-10.

13.  Zhao Y, Xu L, Ding S, Lin N, Ji Q, Gao L, Su Y, He B*, Pu J*. Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy. J Pineal Res. 2017;62(3).

14.  Wei A, Gu Z, Li J, Liu X, Wu X, Han Y*, Pu J*. Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights From the Meta-Analysis of 4894 Patients From 24 Randomized Double-Blind Placebo-Controlled Clinical Trials. J Am Heart Assoc. 2016;5(11).

15.  Gao Y, Zhao Y, Yuan A, Xu L, Huang X, Su Y, Gao L, Ji Q, Pu J*, He B*. Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice. Exp Cell Res. 2018 Oct 15;371(2):301-10.

16.  Sheng X, Ding S, Ge H, Sun Y, Kong L, He J, Pu J*, He B*. Intracoronary infusion of alprostadil and nitroglycerin with targeted perfusion microcatheter in STEMI patients with coronary slow flow phenomenon. Int J Cardiol. 2018;265:6-11.

17.  Zhao YC, Xu LW, Ding S, Ji QQ, Lin N, He Q, Gao LC, Su YY, Pu J*, He B*. Nuclear receptor retinoid-related orphan receptor α deficiency exacerbates high-fat diet-induced cardiac dysfunction despite improving metabolic abnormality. Biochim Biophys Acta. 2017;1863(8):1991-2000.

18.  Sun B, Li X, Liu X*, Ge X, Lu Q, Zhao X, Pu J*, Xu J, Zhao H*. Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2017;16(1):111.

19.  Ji Q, Zhao Y, Yuan A, Pu J*, He B*. Deficiency of liver-X-receptor-α reduces glucose uptake and worsens post-myocardial infarction remodeling. Biochem Biophys Res Commun. 2017;488(3):489-95.

20.  Ge H, Ding S, An D, Li Z, Ding H, Yang F, Kong L, Xu J, Pu J*, He B*. Frame counting improves the assessment of post-reperfusion microvascular patency by TIMI myocardial perfusion grade: Evidence from cardiac magnetic resonance imaging. Int J Cardiol. 2016;203:360-6.

21.  Deng KQ, Wang A, Ji YX, Zhang XJ, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu XY, Zhao Y, Gao L, Yang Q, Zhu XH, Wei X, Pu J*, Li H*. Suppressor of IKKε is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016;7:11432.

22.  Jiang H, Han Y, Xu C, Pu J*, He B*. Noninvasive Positive Pressure Ventilation in Chronic Heart Failure. Can Respir J. 2016;2016:3915237.

23.  Ding S, Du YP, Lin N, Su YY, Yang F, Kong LC, Ge H, Pu J*, He B*. Effect of glucagon-like peptide-1 on major cardiovascular outcomes in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Int J Cardiol. 2016;222:957-62.

24.  Ying X, Zhao Y, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J*, He B*. Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling. Hypertension. 2016;68(5):1160-70.

25.  Ding S, Zhao H, Qiao ZQ, Yang F, Wang W, Gao LC, Kong LC, Xu RD, Ge H, Shen XD, Pu J*, He B*. Early resolution of ST-segment elevation after reperfusion therapy for acute myocardial infarction: Its relation to echocardiography-determined left ventricular global and regional function and deformation. J Electrocardiol, 2015;48(2): 241-8.

26.  Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J*, He B*. Vitamin d Receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal, 2015; 22(8): 633-50.

27.  He Q, Pu J*, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL*, He B*. Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury. Circ Heart Fail, 2014;7(6): 1032-41.

28.  Lyu T, Zhao Y, Zhang T, Zhou W, Yang F, Ge H, Ding S, Pu J*, He B*. Natriuretic peptides as an adjunctive treatment for acute myocardial infarction. Int Heart J, 2014;55(1):8-16.

29.  Xu R, Zhao Y, Ding S, Pu J*, He B*. Autologous transplantation of bone-marro/blood-derived cells for chronic ischemic heart disease: a systematic review and meta-analysis. Can J Cardiol. 2014;30(11):1370-7.

30.  Lyu T, Zhao Y, Zhang T, Zhou W, Yang F, He Q, Yuan A, Yao T, Pu J*, He B*. Effect of statin pretreatment on myocardial perfusion in patients undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis. Clin Cardiol, 2013; 36(9):E17-24

31.  Shan P, Pu J *, Yuan A, Shen L, Shen L, Chai D, He B*. RXR agonists inhibit oxidative stress-induced apoptosis in H9c2 rat ventricular cells. Biochem Biophys Res Commun. 2008;375(4):628-33.

32.  Pu J, Ding S, Ge H, Han Y, Lin R, Guo J, Lin R, Su X, Zhang H, Chen L, He B. EARLY-MYO Investigators. (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation. 2017; 136(16):1462-73.

33.  Pu J, Mintz GS, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments. J Am Coll Cardiol. 2014; 63(21):2220-33.

34.  Pu J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau W, Ma XL, He B. Cardiomyocyte Expressed Farnesoid-X-Receptor is a Novel Apoptosis Mediator and Contributes to Myocardial Ischemia/Reperfusion Injury. Eur Heart J. 2013; 34:1834-45.

35.  Pu J, Mintz GS, Brilakis ES, Banerjee S, Abdel-Karim AR, Maini B, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J.2012; 33:372-83.

36.  Pu J, Shan P, Ding S, Qiao Z, Jiang L, Song W, Du Y, Shen J, Shen L, Jin S, He B. Gender differences in epicardial and tissue-level reperfusion in patients undergoing primary angioplasty for acute myocardial infarction. Atherosclerosis. 2011;215(1):203-8.

37.  Pu J, Shan P, Ding S, Qiao Z, Jiang L, Song W, Du Y, Shen J, Shen L, Jin S, He B. Factors affecting TIMI myocardial perfusion frame count: Insights of myocardial tissue-level reperfusion from a novel index for assessing myocardial perfusion. Chin Med J (Engl).2011;124(6) :873-8.

38.  Pu J, Ding S, Shan P, Qiao Z, Song W, Du Y, Shen J, Jin S, He B. Comparison of epicardial and myocardial perfusions after primary coronary angioplasty for ST-elevation myocardial infarction in patients younger than and older. Aging Clin Exp Res. 2010; 22(4):295-302.

39.  Pu J, Ding S, He B.  Rebuttal: TIMI myocardial perfusion frame count: an angiographic method to assess flow in the myocardium but not in the epicardial artery. Catheter Cardiovasc Interv. 2010;76(7):1073-5.

40.  Pu J, Zhang C, Quan X, Zhao G, Lv J, Li B, Bai R, Liu N, Ruan Y, He B. Effects of potassium aspartate and magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart. J Huazhong Univ Sci Technolog Med Sci. 2008;28(5):517-9.

41.  Song H#, Pu J#, Wang L, Wu L, Xiao J, Liu Q, Chen J, Zhang M, Liu Y, Ni M, Mo J, Zheng Y, Wan D, Cai X, Cao Y, Xiao W, Ye L, Tu E, Lin Z, Wen J, Lu X, He J, Peng Y, Su J, Zhang H, Zhao Y, Lin M, Zhang Z. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. Autophagy. 2015;11(8):1308-25.

42.  Jiang M#, Pu J#, He B. The short to mid-term effect of bone marrow derived cell transfer on diastolic function after acute myocardial infarction. Int J Cardiol. 2011;153(1):87-8.

43.  Ding S#, Pu J#, Qiao ZQ , Shan P, Song W, Du Y, Shen JY, Jin SX, Sun Y, Shen L, Lim YL, He B. TIMI myocardial perfusion frame count: a new method to assess myocardial perfusion and its predictive value for short-term prognosis. Catheter Cardiovasc Interv. 2010;75(5):722-32.

44.  Chen BH, Shi RY, An DA, Wu R, Wu CW, Hu J, Manly A, Kaddurah H, He J, Pu J, Xu JR, Wu LM. BOLD cardiac MRI for differentiating reversible and irreversible myocardial damage in ST segment elevation myocardial infarction. Eur Radiol. 2018 Jul 9. doi: 10.1007/s00330-018-5612-y. [Epub ahead of print]

45.  Wei AH, Gu ZC, Zhang C, Ding YF, Liu D, Li J, Liu XY, Lin HW, Pu J. Increased risk of myocardial infarction with dabigatran etexilate: fact or fiction? A critical meta-analysis of over 580,000 patients from integrating randomized controlled trials and real-world studies. Int J Cardiol. 2018 Sep 15;267:1-7.

46.  Peng S, Xu LW, Che XY, Xiao QQ, Pu J, Shao Q, He B. Atorvastatin Inhibits Inflammatory Response, Attenuates Lipid Deposition, and Improves the Stability of Vulnerable Atherosclerotic Plaques by Modulating Autophagy. Front Pharmacol. 2018;9:438.

47.  Cai Z, Li J, Zhuang Q, Zhang X, Yuan A, Shen L, Kang K, Qu B, Tang Y, Pu J, Gou D, Shen J. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways. Exp Mol Med. 2018;50(4):45.

48.  Gu ZC, Zhou LY, Shen L, Zhang C, Pu J, Lin HW, Liu XY. Non-vitamin K Antagonist Oral Anticoagulants vs. Warfarin at Risk of Fractures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2018;9:348.

49.  Sun LY, Cai ZY, Pu J, Li J, Shen JY, Yang CD, He B. 5-Aminosalicylic Acid Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats by Increasing the Expression of Nur77. Inflammation. 2017;40(3):806-17.

50.  Wang Z, Wang L, Su X, Pu J, Jiang M, He B. Rational transplant timing and dose of mesenchymal stromal cells in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials. Stem Cell Res Ther. 2017;8(1):21.

51.  Zhao H, Lee AP, Li Z, Qiao Z, Fan Y, An D, Xu J, Pu J, Shen X, Ge H, He B. Impact of Intramyocardial Hemorrhage and Microvascular Obstruction on Cardiac Mechanics in Reperfusion Injury: A Speckle-Tracking Echocardiographic Study. J Am Soc Echocardiogr. 2016;29(10):973-82.

52.  Jiang L, Chen Y, Huang X, Yuan A, Shao Q, Pu J, He B. Selective activation of CB2 receptor improves efferocytosis in cultured macrophages. Life Sci. 2016;161:10-8.

53.  Jiang M, Pu J, Yao J, Xu J, He B. An acromegaly-induced cardiomyopathy mimicking amyloidosis: (Manifestation of acromegaly-induced-cardiomyopathy). Int J Cardiol. 2016 Jul 15;215:60-1.

54.  Kang SJ, Mintz GS, Pu J, Sum ST, Madden SP, Burke AP, Xu K, Goldstein JA, Stone GW, Muller JE, Virmani R, Maehara A. Combined IVUS and NIRS Detection of Fibroatheromas: Histopathological Validation in Human Coronary Arteries. JACC Cardiovasc Imaging, 2015;8(2): 184-94.

55   Song W, Pu J, He B. Tanshinol protects human umbilical vein endothelial cells against hydrogen peroxide induced apoptosis. Mol Med Rep. 2014;10(5):2764-70.

56.  Jiang M, Mao JL, Pu J, He B. Timing of Early Angiography in Non-ST Elevation Acute Coronary Syndrome. J Invasive Cardiol, 2014;26(2):47-54 .

57.  Jiang M, Pu J, Shen XD, He B. Prednisone induced two-way myocardial development in a patient with systemic lupus erythematosus. BMJ Case Rep. 2014 Apr 30;2014.

58.  Song W, Zhang T, Pu J, Shen L, He B. Incidence and risk of developing contrast-induced acute kidney injury following intravascular contrast administration in elderly patients. Clin Interv Aging, 2014;9:85-93.

59.  Guo J, Maehara A, Guo N, Ashida K, Chirumamilla A, Shang Y, Pu J, Sanidas E, Moses JW, Leon MB, Weisz G, Stone GW, Mintz GS, Ochiai M. Virtual histology intravascular ultrasound comparison of coronary chronic total occlusions versus non-occlusive lesions. Int J Cardiovasc Imaging, 2013;29(6):1249-54.

60.  Guo J, Maehara A, Mintz GS, Ashida K, Pu J, Shang Y, Leon MB, Stone GW, Moses JW, Ochiai M. A virtual histology intravascular ultrasound analysis of coronary chronic total occlusions. Catheter Cardiovasc Interv, 2013;81(3):464-70.

61.  Jiang M, Mao JL, Pu J, He B. Midterm effects and clinical benefits of left ventricular vs biventricular pacing in heart failure. Can J Cardiol, 2013;9(6):727-33.

62.  Jiang M, Gong XR, Zhou SH, Pu J, Mao JL, He B. A comparison of steep and shallow needle trajectories in blind axillary vein puncture. Pacing Clin Electrophysiol, 2013;36(9):1150-5.

63.  Shang Y, Mintz GS, Pu J, Guo J, Kobayashi N, Franklin-Bond T, Leon MB, Moses JW, Maehara A, Shimizu T, Yakushiji T. Bypass to the left coronary artery system may accelerate left main coronary artery negative remodeling and calcification. Clin Res Cardiol, 2013;102(11):831-5.

64.  Wang PF, Jiang LS, Pu J, Huang XJ, Song W, Du YP, He B. Cannabinoid-2 receptor activation protects against infarct and ischemia-reperfusion heart injury. J Cardiovasc Pharmacol. 2012;59(4):301-7.

65.  Wang X, Zhang Y, Pu J, Shen L, He B. Effects of testosterone on norepinephrine release in isolated rat heart. J Huazhong Univ Sci Technolog Med Sci. 2012;32(1):42-6.

66.  Shen LH, Wan F, Shen L, Ding S, Gong XR, Qiao ZQ, Du YP, Song W, Shen JY, Jin SX, Pu J, Yao TB, Jiang LS, Li WZ, Zhou GW, Liu SW, Han YL, He B. Pharmacoinvasive therapy for ST elevation myocardial infarction in China: a pilot study. J Thromb Thrombolysis. 2012;33(1):101-8.

67.  Shao Q, Shen LH, Hu LH, Pu J, Jing Q, He B. Atorvastatin suppresses inflammatory response induced by oxLDL through inhibition of ERK phosphorylation, IκBα degradation and COX-2 expression in murine macrophages. J Cell Biochem. 2012;113(2):611-8.

68.  Sanidas EA, Maehara A, Mintz GS, Kashiyama T, Guo J, Pu J, Shang Y, Claessen B, Dangas GD, Leon MB, Moses JW, Stone GW, Ueda Y. Angioscopic and Virtual Histology Intravascular Ultrasound Characteristics of Culprit Lesion Morphology Underlying Coronary Artery Thrombosis. Am J Cardiol. 2011;107(9):1285-90.

69.  Lee JB, Mintz GS, Lisauskas JB, Biro SG, Pu J, Sum ST, Madden SP, Burke AP, Goldstein J, Stone GW, Virmani R, Muller JE, Maehara A.Histopathologic Validation of the Intravascular Ultrasound Diagnosis of Calcified Coronary Artery Nodules. Am J Cardiol. 2011;108(11):1547-51.

70.  Shao Q, Shen LH, Hu LH, Pu J, Ge H, Han ZH, Qi MY, Li WQ, Tian FJ, Jing Q. Nuclear receptor Nur77 suppresses inflammatory response partially dependent on COX-2 in macrophages induced by oxidized low-density lipoprotein. J Mol Cell Cardiol. 2010;49(2):304-11.

71   Hao MX, Jiang LS , Fang NY, Pu J , Hu LH, Shen LH, Song W, He B. The cannabinoid WIN55, 212-2 protects against oxidized LDL -induced inflammatory response in murine macrophages. J Lipid Res. 2010;51(8):2181-90.

72.  Zhou L, Shen LH, Hu LH, Ge H, Pu J, Chai DJ, Shao Q, Wang L, Zeng JZ, He B. Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol Cell Biochem. 2010;335(1-2):283-9.

73.  Jiang LS, Pu J, Han ZH, Hu LH, He B. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. Cardiovasc Res. 2009;81(4):805-13.

74.  Chai D, Wang B, Shen L, Pu J, Zhang XK, He B. RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells. Free Radic Biol Med. 2008;44(7):1334-47.

75.  Shen L, Zhou L, Wang BY, Pu J, Hu LH, Chai DJ, Wang L, Zeng JZ, He B. Oxidized low-density lipoprotein induces differentiation of RAW264.7 murine macrophage cell line into dendritic-like cells. Atherosclerosis. 2008;199(2):257-64.

76.  Jiang M, Wang B, Wang C, He B, Fan H, Shao Q, Gao L, Liu Y, Yan G, Pu J. In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1alpha-modified endothelial progenitor cells (Ad-HIF-1a-modified EPC for angiogenesis). Int J Biochem Cell Biol. 2008;40(10):2284-95.

77.  Bai R, Yang XY, Song Y, Lin L, Lü JG, Ching CK, Pu J, Kam R, Hsu LF, Zhang CT, Teo WS, Wang L. Impact of left ventricular epicardial and biventricular pacing on ventricular repolarization in normal-heart individuals and patients with congestive heart failure. Europace. 2006;8:1002-10.

78.  Bai R, Lu J, Pu J, Liu N, Zhou Q, Ruan Y, Niu H, Zhang C, Wang L, Kam R.  Left ventricular epicardial activation increases transmural dispersion of repolarization in healthy, long QT, and dilated cardiomyopathy dogs. Pacing Clin Electrophysiol. 2005;28:1098-106.

79.  You Binquan, Pu J, Liu Nian , Yu Ronghui , Ruan Yanfei, Li Yang , Wang Lin. Effect of lidocaine and amiodarone on transmural heterogeneity of ventricular repolarization in isolated rabbit hearts model of sustained global ischemia. J Huazhong Univ Sci Technolog (Med Sci). 2005;25:400-3.

80.  Peng F, Zeng XC, He XH, Pu J, Li WX, Zhu ZH, Liu H. Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin. Eur J Biochem 2002;269:4468-75.

在冠心病，高血压病，心律失常，先天性心脏病，心力衰竭等心血管疾病的诊断和治疗方面有丰富的临床经验；冠脉影像学诊断和冠脉介入治疗。

1. 国家重点研发专项，编号2018YFC1312800、“心脑血管疾病`协防共管’创新健康管理模式的开发与效果评价”、2018/09-2020/12、1534万元、在研、项目总负责人及首席科学家。

2. 国家杰出青年基金,编号81625002、“心血管内科学 (冠心病事件链机制及干预)”、2017/01-2020/12、350万元、在研、主持。

3. 上海市科委优秀学术带头人计划，编号18XD1402400、“生物钟核受体NR1F1在急性心梗心肌组织水平灌注不良中的关键保护作用”、2018/05-2021/4、40万元、在研、主持。

4. 上海市申康临床创新行动计划项目，编号16CR3034A、“基于三维定量心肌微循环功能的血流储备评估新技术的建立与应用”、2016/12-2019/06、50万元、在研、主持。

5. 上海市教委高峰高原人才项目，编号20152209、“以TMPFC为核心的新型急性心肌死心肌组织水平再灌注临床技术的建立与优化应用”、2015/01-2017/12、100万元、结题、主持。

6. 国家自然科学基金面上项目，编号81470389、“核受体FXR-SHP级联通路参与心肌细胞肥大与心肌成纤维细胞增殖的双重调控及其分子机制”、2015/01- 2018/12、75万元、在研、主持。

7. 国家自然科学基金重点项目，编号81330006、“核受体LXRα/LXRβ差异性SUMO化修饰在心肌梗死后心肌组织重构中的关键作用”、 2014/01-2018/12，290万元、在研、参与（排名第二）。

8. 上海市科委基础研究重点项目，编号14JC1404500 , “肝X受体不同亚型在急性心肌梗死及其后续心肌重构与功能重建中的靶点作用及其关键调控机制”、2014/01-2016/12 ，50万元、已结题、主持。

9. 国家自然科学基金面上项目，编号81270282、“FXR受体通过线粒体途径诱导心肌缺血再灌注损伤的新机制：孤儿受体SHP的关键作用”、2013/01-2016/12、70万元、已结题、主持。

10. 国家教育部新世纪优秀人才计划，编号 NCET-12-0352、“RAR相关孤儿受体在动脉粥样硬化斑块稳定性中的作用及其机制 ”、 2013/01-2015/12 ，50万元、已结题、主持。

11. 上海市曙光计划人才项目，编号12SG-22，“视黄酸相关受体ROR：调控动脉粥样硬化斑块稳定性的新靶点”、2013/01-2015/12，15万元、已结题、主持。

12. 上海市科委国际合作课题，编号12410708300，“急性心肌梗死心肌组织水平灌注的新型评估技术体系建立与优化应用”、2012/01¬-2014/12，25万元、已结题、主持。

13. 国家自然科学基金面上项目，编号81070176、“缺血心肌再灌注及梗死后重塑过程中视黄醛X受体与NR4A1孤核受体通路在线粒体水平的交叉对话及机制”、2011/01-2013/12，32万元、已结题、主持。

14. 上海市教委高校选拔优青专项基金，编号:JDY06034，“RXR核受体：新的抗心力衰竭的药物靶点”、 2007/1-2009/12、10万元、已结题、主持。

15. 国家自然科学基金青年基金，编号30600242、“独特的RXR受体 /Nur77受体信号通路参与心肌肥厚和凋亡的双重调控的分子机制研究”、2007/01-2009/12，23万元、已结题、主持。