毛海萍

医疗特长：长期从事内科肾脏疾病的临床、教学及科研工作。擅长慢性肾脏病和慢性肾衰竭的诊治，腹膜透析治疗和管理研究方向：慢性肾脏病分子机制研究、腹膜透析的临床和相关基础研究主要教育和工作经历：2003年毕业于中山大学，获博士学位，后一直在中山大学附属第一医院肾内科工作。2001年-2004年期间赴美国波士顿大学医疗中心肾内科进行访问学习。社会兼职：广东省医师协会肾脏病分会常委，中国药理学会肾脏药理专业委员会常委论著：发表SCI 文章58篇，其中第一作者/通讯作者22篇，包括JASN, JBC, Autophagy等(1)Peng X, Wang Y, Li H, Fan J, Shen J, Yu X, Zhou Y*,Mao H*.ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury.Cell Death Dis. 2019;10(4):253.(2)Li W, Xu R, Wang Y, Shen J, Li Z, Yu X, Mao H*.Association of body mass index and uncontrolled blood pressure with cardiovascular mortality in peritoneal dialysis patients. J Hum Hypertens. 2019;33(2):106-114.(3)Cao S, Li S, Wang Y, Shen J, Zhou Y, Li H, Yu X, Mao H*.Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis. Biomed Res Int. 2018;2018:2649585.(4)Wang Y, Xiong L, Xu Q, Li W, Peng X, Shen J, Qiu Y, Yu X, Mao H*.Association of left ventricular systolic dysfunction with mortality in incident peritoneal dialysis patients.Nephroogy. 2018;23(10):927-932.(5)Li W, Xiong L, Fan L, Wang Y, Peng X, Rong R, Qiu Y, Shen J, Lin J, Yu X, Mao H*.Association of baseline, longitudinal serum high-sensitive C-reactive protein and its change with mortality in peritoneal dialysis patients. BMC Nephrol. 2017;18(1):211.(6) Li H, Peng X, Wang Y, Cao S, Xiong L, Fan J, Wang Y, Zhuang S, Yu X, Mao H. Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis. Autophagy. 2016 Sep;12(9):1472-86.(7) Zhou Y, Cao S, Li H, Peng X, Wang Y, Fan J, Wang Y, Zhuang S, Yu X, Mao H*. Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis. Am J Pathol. 2016 Feb 3(8) Xiong L, Cao S, Xu F, Zhou Q, Fan L, Xu Q, Yu X, Mao H. Association of Body Mass Index and Body Mass Index Change with Mortality in Incident Peritoneal Dialysis Patients. Nutrients. 2015 Oct 13;7(10):8444-55(9) Xu Q, Xiong L, Fan L, Xu F, Yang Y, Li H, Peng X, Cao S, Zheng Z, Yang X, Yu X, Mao H. Association of Pulmonary Hypertension with Mortality in Incident Peritoneal Dialysis Patients. Perit Dial Int. 2015 Sep-Oct;35(5):537-44(10) Xiong L, Fan L, Xu Q, Zhou Q, Li H, Peng X, Yang Y, Wang Y, Yu X, Mao H. Faster Transport Status and Mortality in Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis. Blood Purif. 2015;40(2):160-6(11) Zhang B, Rong R, Li H, Peng X, Xiong L, Wang Y, Yu X, Mao H. Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury. Mol Med Rep. 2015 Mar;11(3):1793-9.(12) Huang N, Chen J, Fan L, Zhou Q, Xu Q, Xu R, Xiong L, Yu X, Mao H. High peritoneal transport status was not associated with mortality in peritoneal dialysis patients with diabetes. PLoS One. 2014 Oct 16;9(10):e110445(13) Xu Q, Xu F, Fan L, Xiong L, Li H, Cao S, Lin X, Zheng Z, Yu X, Mao H. Serum potassium levels and its variability in incident peritoneal dialysis patients: associations with mortality. PLoS One. 2014 Jan 27;9(1):e86750(14) Cao S, Li S, Li H, Xiong L, Zhou Y, Fan J, Yu X, Mao H. The potential role of HMGB1 release in peritoneal dialysis-related peritonitis. PLoS One. 2013;8(1):e54647(15) Zhang L, Cao T, Li Z, Wen Q, Lin J, Zhang X, Guo Q, Yang X, Yu X, Mao H. Clinical outcomes of peritoneal dialysis patients transferred from hemodialysis: a matched case-control study. Perit Dial Int. 2013 May-Jun;33(3):259-66(16)Mao H#, Li Z, Zhou Y, Li Z, Zhuang S, An X, Zhang B, Chen W, Nie J, Wang Z, Borkan SC, Wang Y, Yu X.HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol. 2008;295(1):F202-14.(17)Ruchalski K, Mao H#, Li Z, Wang Z, Gillers S, Wang Y, Mosser DD, Gabai V, Schwartz JH, Borkan SC. Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem. 2006;281(12):7873-80.(18)Mao H#, Wang Y, Li Z, Ruchalski KL, Yu X, Schwartz JH, Borkan SC. Hsp72 interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion. J Biol Chem. 2004;279(15):15472-80.(19)Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC. hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells. J Biol Chem. 2003;278(20):18214-20.其他主要工作成绩（比如获奖情况）：主持和承担各级科研项目16项，其中国家自然科学基金5项。

1) 2001年广东省卫生厅基金 第一负责人

2)2003年广东省自然科学基金 第二负责人

3)2004年广东省自然科学基金团队项目 骨干队员

4)2001年中山医科大学教学基金 第二负责人

1. Haiping Mao, Wang YH, Li ZJ, Ruchalski, K.L., Yu XQ, Schwartz, J.H. and S.C. Borkan. Hsp72 interacts with Paxillin and facilitates the reassemble of focal adhesion during recovery from ATP depletion. J. Biol Chem. 279(15):15472-15480, 2004.

2. Haiping Mao, Li, F., Ruchalski, K.L., Mosser, D.D., Wang, Y-H., Schwartz, J.H. and S.C. Borkan. Hsp72 prevents focal adhesion kinase (FAK) degradation in ATP depleted renal epithelial cells. J. Biol Chem. 278 (20):18214-18220, 2003.

3. Ruchalski, K.L., Haiping Mao, Singh,S.K., Wang, Y-H., Mosser, D.D., Li, F., Schwartz, J.H. and S.C. Borkan. Hsp72 inhibits apoptosis-inducing factor release in ATP- depleted renal epithelial cells. Am J Physiol (Cell Physiol) 285:C1483-C1493, 2003.

4. Li, F., Haiping Mao, Ruchalski, K.L., Wang, Y-H., Choy, W., Schwartz, J.H. and S.C. Borkan. Heat stress prevents mitochondrial injury in ATP depleted renal epithelial cells Am J Physiol 283 (Cell Physiol) C917-C226, 2002.

5. 毛海萍，余学清，李志坚等，热休克蛋白72抑制ATP耗竭时细胞色素C释放所诱导的肾小管上皮细胞凋亡。 中华肾脏病杂志，2003，19(3)：6-10

6. 毛海萍，余学清等，细胞色素C在ATP耗竭诱导的肾小管上皮细胞凋亡中的作用。中华肾脏病杂志 2003，19(2)：90-94

尿路感染、原发性肾病综合征、急慢性肾炎、狼疮性肾炎、急慢性肾衰竭及其并发症等诊断与治疗。